Evidence map›Paper›PMID 40548732›Full record

ArticlemSphere2025

The pre-mRNA splicing modulator pladienolide B inhibits

Sierra L Love, Megan C McKeon, Henrik Vollmer, Joshua C Paulson, Nanami Oshimura, Olivia Valentine, Sébastien C Ortiz, Christina M Hull, Aaron A Hoskins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sierra L LoveGenetics Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-3254-9009
Megan C McKeonGenetics Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-2260-6367
Henrik VollmerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joshua C PaulsonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nanami OshimuraDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Olivia ValentineDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sébastien C OrtizDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Christina M HullDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-4529-1775
Aaron A HoskinsDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-9777-519X

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
NIH Diversity Supplement for Sebastien Ortiz on R01 AI137409R01AI137409 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 2018 to 2022
$2.1M
Badger ChallengeEdward P. Evans FoundationNational Institute of Allergy and Infectious Diseases R01AI137409NIAID NIH HHS R01 AI137409NIGMS NIH HHS 5T32GM007133NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antifungal AgentsCryptococcus neoformansEpoxy CompoundsMacrolidesRNA PrecursorsRNA SplicingGene Expression ProfilingGene Expression Regulation, FungalHumansIntronsMicrobial Sensitivity TestsSpores, FungalAntifungal AgentsEpoxy CompoundsMacrolidespladienolide BRNA PrecursorsantifungalC. neoformansinhibitorpre-mRNAsplicing

Identifiers

PMID40548732
PMCPMC12306170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.