Evidence map›Paper›PMID 40548720›Full record

ArticleJournal of virology2025

Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca

Shan Wang, Shanshan Tang, Yuxin Zhou, Qifei An, Mengxing Du, Xiujuan Yang, Peng Zou, Li Tang, Yufeng Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shan WangShanxi Key Laboratory of Functional Proteins, School of Basic Medical Sciences and Pharmacy, Shanxi Medical University, Taiyuan, China.
Shanshan TangShanxi Key Laboratory of Functional Proteins, School of Basic Medical Sciences and Pharmacy, Shanxi Medical University, Taiyuan, China.
Yuxin ZhouShanxi Key Laboratory of Functional Proteins, School of Basic Medical Sciences and Pharmacy, Shanxi Medical University, Taiyuan, China.
Qifei AnShanxi Key Laboratory of Functional Proteins, School of Basic Medical Sciences and Pharmacy, Shanxi Medical University, Taiyuan, China.
Mengxing DuShanxi Key Laboratory of Functional Proteins, School of Basic Medical Sciences and Pharmacy, Shanxi Medical University, Taiyuan, China.
Xiujuan YangDepartment of Public Health Laboratory Sciences, School of Public Health, Shanxi Medical University, Taiyuan, China.
Peng ZouShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li TangShanxi Key Laboratory of Functional Proteins, School of Basic Medical Sciences and Pharmacy, Shanxi Medical University, Taiyuan, China.ORCID 0000-0003-2741-3545
Yufeng YuShanxi Key Laboratory of Functional Proteins, School of Basic Medical Sciences and Pharmacy, Shanxi Medical University, Taiyuan, China.ORCID 0000-0001-5366-8555

Funding

Applied Basic Research Project of Shanxi Province, China 202203021221189National Natural Science Foundation of China 32301421National Natural Science Foundation of China 82102388
6 · The paper itself

Abstract

Zika virus (ZIKV) infection of neuronal cells leads to endoplasmic reticulum (ER) stress, which is one of the key causes of neuronal damage. However, how ZIKV mediates ER stress has not been fully understood. Here, we observed that ZIKV infection of astrocytes elevated Sarco/endoplasmic reticulum Ca IMPORTANCE: Zika virus (ZIKV) infection induces intracellular Ca

Indexed as

Endoplasmic Reticulum StressSarcoplasmic Reticulum Calcium-Transporting ATPasesViral Nonstructural ProteinsZika VirusZika Virus InfectionAnimalsAstrocytesCalciumHomeostasisHumansMiceMice, Inbred BALB CVirus ReplicationCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesViral Nonstructural ProteinsATP2A2Ca2+ homeostasisER stressNS2ASERCA2Zika virus

Identifiers

PMID40548720
PMCPMC12282174

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.