ArticleMicrobiology spectrum2025
Exploring the antimicrobial activity of pantothenamides against uropathogenic
Alicia A DeColli, David J Meyers, Arina Ranjit, James Paule, Erika Serrano-Diaz, Kimberly M Bockley, Laura M Ensign, Rana Rais, Caren L Freel Meyers
Abstract read
In one paragraphArticle in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Alicia A DeColli *Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
David J Meyers *Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7010-6930 Arina RanjitDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
James PauleDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Erika Serrano-DiazDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kimberly M BockleyDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Laura M EnsignDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rana RaisDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Caren L Freel MeyersDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1458-0897 Funding
PHARMACOLOGY TRAINING GRANTT32GM008763 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FREEL MEYERS, CAREN L. · 2000 to 2019
$6.1MPharmacology and Molecular Sciences Training Program: Enhancing Inclusivity Through Universal Design for Learning in Graduate CoursesT32GM135083 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Caren L. Freel Meyers · 2020 to 2026
$3.3MTargeting DXP synthase in bacterial metabolismR01AI161020 · NIAID · JOHNS HOPKINS UNIVERSITY · PI FREEL MEYERS, CAREN L. · 2021 to 2025
$2.7MAcquisition of a 500 MHz NMR Spectrometer to Support Small-Molecule Chemistry at Johns Hopkins Medical SchoolS10OD034217 · OD · JOHNS HOPKINS UNIVERSITY · PI BHAT, SHRIDHAR · 2024 to 2024
$425kFlight Attendant Medical Research InstituteNIAID NIH HHS R01 AI161020NIGMS NIH HHS T32 GM008763NIGMS NIH HHS T32 GM135083NIH HHS R01AI161020NIH HHS S10 OD034217NIH HHS S10OD034217NIH HHS T32GM008763NIH HHS T32GM135083
6 · The paper itselfAbstract
Metabolic processes required for bacterial pathogens to adapt in the host are potential targets for the development of much-needed new antimicrobial agents. The bacterial central metabolic enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) is required for the synthesis of essential isoprenoids, thiamin diphosphate (ThDP), and pyridoxal phosphate (PLP) and is believed to function in bacterial adaptations requiring these metabolites. DXPS inhibition impairs a PLP-dependent adaptation of Uropathogenic
Indexed as
Anti-Bacterial AgentsEscherichia coli InfectionsPantothenic AcidUropathogenic Escherichia coliAnimalsCoenzyme AEscherichia coli ProteinsFemaleHumansMiceMicrobial Sensitivity TestsUrinary Tract InfectionsAnti-Bacterial AgentsCoenzyme AEscherichia coli ProteinsPantothenic Acidantimicrobial activityCoA biosynthesisdrug discoveryDXP synthaseN5-Panpantothenamidesurinary tract infectionuropathogenic E. coli
Identifiers
PMID40548707
PMCPMC12323621
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