Evidence map›Paper›PMID 40548505›Full record

ArticleJournal of the American Heart Association2025

Association Between Physical Activity Dose and Mental Health Among Stroke Survivors.

Ajith Kumar Vemuri, Seyyed Sina Hejazian, Alireza Vafaei Sadr, Aishwarya Chandrasekaran, Sasan Bahrami, Shouhao Zhou, Jonathan Hakun, Christopher Sciamanna, Vida Abedi, Ramin Zand

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ajith Kumar VemuriDepartment of Neurology, College of Medicine Pennsylvania State University Hershey PA.ORCID 0009-0005-5603-1732
Seyyed Sina HejazianDepartment of Neurology, College of Medicine Pennsylvania State University Hershey PA.ORCID 0000-0002-8448-1539
Alireza Vafaei SadrDepartment of Public Health Sciences, College of Medicine Pennsylvania State University Hershey PA.ORCID 0000-0002-5733-6678
Aishwarya ChandrasekaranDepartment of Computer and Information Sciences University of Delaware Newark DE.ORCID 0009-0001-1378-1198
Sasan BahramiDepartment of Neurology, College of Medicine Pennsylvania State University Hershey PA.
Shouhao ZhouDepartment of Public Health Sciences, College of Medicine Pennsylvania State University Hershey PA.ORCID 0000-0002-8124-5047
Jonathan HakunDepartment of Neurology, College of Medicine Pennsylvania State University Hershey PA.
Christopher SciamannaDepartment of Public Health Sciences, College of Medicine Pennsylvania State University Hershey PA.
Vida AbediDepartment of Public Health Sciences, College of Medicine Pennsylvania State University Hershey PA.ORCID 0000-0001-7689-933X
Ramin ZandDepartment of Neurology, College of Medicine Pennsylvania State University Hershey PA.ORCID 0000-0002-9477-0094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough physical activity correlates with reduced depressive symptoms among survivors of stroke, how frequency, intensity, and duration of physical activity relate to mental health is unknown. This study aims to find the association of physical activity doses recommended in 2011, 2014, and 2021 American Heart Association/American Stroke Association guidelines with mental health burden (number of days of poor mental health). Analysis was expanded to find the optimal dose linked to mental health burden.

methodsWe used data from the 2011 to 2019 Behavioral Risk Factor Surveillance System, a nationally representative survey. The mental health burden between guideline-adherent and nonadherent groups was compared. Propensity score matching was used to balance the 2 groups with respect to sociodemographic factors and comorbidities. The relative difference in mental health burden between the groups is reported. The impact of duration, frequency, and intensity was analyzed using nonlinear regression, adjusting for potential confounders. We further performed a comparative analysis among survivors of myocardial infarction.

resultsSurvivors of stroke who adhered to 2011, 2014, and 2021 guidelines had 0.6, 0.8, and 0.3 fewer days of poor mental health, with relative differences of 11.1%, 14.8%, and 5.8%, respectively. Among survivors of stroke adhering to 2014 guidelines (3-4 sessions/week, 40 minutes/session), younger (18-64) individuals showed greater relative differences in mental health burden at 15.7%. For those adhering to 2021 guidelines (4 moderate 10-minute or 2 vigorous 20-minute sessions), older (≥65) individuals had higher relative differences at 11.1%. Regression analysis showed that the optimal dose is 4 to 6 weekly sessions of moderate physical activity, each lasting 45 minutes.

conclusionsThe findings suggest that physical activity doses recommended in 2011, 2014, and 2021 American Heart Association/American Stroke Association guidelines are associated with lower mental health burden. Furthermore, the amount of physical activity associated with lower mental health may vary by subpopulations (eg, age). Randomized control trials are needed to validate the optimal dose.

Indexed as

DepressionExerciseMental HealthStrokeStroke RehabilitationSurvivorsAdultAgedBehavioral Risk Factor Surveillance SystemFemaleHumansMaleMiddle AgedUnited Statesguidelinesmental healthphysical activitystroke

Identifiers

PMID40548505
PMCPMC12450018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.