ArticleVeterinary medicine and science2025
Therapeutic Effects of Naringin on Bisphenol A-Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Protective effects of panax ginseng against bisphenol a-induced testicular toxicity in rats.International journal of impotence research · 2026Article
- Nutrigenomic Potentials of Phytobiotics Against Heat Stress and Allied Afflictions in Livestock Species-An In Silico Supported Review.Food science & nutrition · 2026Review
- Targeting the Gut Microbiota: Mechanistic Investigation of Polyphenol Modulation of the Gut-Brain Axis in Alzheimer's Disease.International journal of molecular sciences · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
backgroundBisphenol A (BPA) is an endocrine-disrupting chemical, and it is mostly used in plastic industries. Naringin is a potent flavonoid that has been reported to possess several beneficial pharmacological properties such as antioxidant, anti-inflammatory, and antiapoptotic properties.
objectiveThe aim of this study was to determine the protective effect of naringin against the damage induced by BPA in the brain and testes of commercial chicken.
methodsThirty-day-old cockerel chickens were purchased and reared for 6 weeks and subsequently divided into six groups: group A (control), group B (100 ppm BPA-treated), group C (BPA and 100 mg/kg naringin-treated), Group D (BPA and 200 mg/kg naringin-treated), group E (100 mg/kg naringin-treated), and group F (200 mg/kg naringin-treated). BPA was administered via drinking water, while naringin was administered via oral gavage. Analyses such as biochemical assays, hormonal assays, histopathology, and immunohistochemistry were done.
resultsThe results showed a decrease in the level of LH, FSH, and testosterone, an increase in the level of oxidative stress markers (MDA and H
conclusionsNaringin reversed the neurotoxicity and reproductive toxicity of BPA by normalizing the values of the altered parameters. Hence, naringin ameliorated the deleterious effects caused by BPA in both the brain and testes by enhancing the antioxidant defence mechanism.
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