ArticleAdvanced healthcare materials2025
Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Influence of liquid repellency and slipperiness on blood-material interactions.Journal of materials chemistry. B · 2026Article
- Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion.Advanced healthcare materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Platelet transfusion is an indispensable therapy used in contexts ranging from hemorrhagic bleeding to chemotherapy. However, platelet shelf life and quality deteriorate during storage in a process termed the platelet storage lesion (PSL), resulting in chronic shortages globally. The PSL is thought to be partially attributed to the bio-incompatible polyvinyl chloride (PVC) storage bags that promote protein fouling and platelet adhesion. Developing platelet-friendly materials is therefore essential for improving platelet storage quality. This study aimed to delineate the contributions of protein adsorption and platelet adhesion to the progression of the PSL. Hydrophilic coatings are screened to identify those which resist protein and platelet adhesion most effectively. These coatings are translated into mini-platelet bags and tested in long-term standard blood banking conditions. Significant reductions in platelet adhesion after 7-day storage do not affect platelet quality. Proteomic characterization of the bag surfaces revealed dynamic changes in the protein coronas on coated and uncoated bag over time, but are uncorrelated with platelet quality. This research demonstrates a method to identify platelet-compatible coatings suitable for long-term storage, as well as a novel approach to characterize the surface of blood storage bags.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.