Evidence map›Paper›PMID 40548390›Full record

ArticleDrug delivery2025

Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination.

Victor A Garcia, Paulina M Eberts, Brenda M Ogle, Casim A Sarkar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Victor A GarciaDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Paulina M EbertsDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota, USA.
Brenda M OgleDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Casim A SarkarDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

Analysis and Engineering of Cell SignalingR35GM136309 · NIGMS · UNIVERSITY OF MINNESOTA · PI Casim Sarkar · 2020 to 2026
$2.3M
Biacore T200 surface plasmon resonance instrumentS10OD021539 · OD · UNIVERSITY OF MINNESOTA · PI HAWKINSON, JON E · 2016 to 2016
$344k
An ultra-selective drug delivery platform technology using modular viral fusogen-actuated liposomesF31CA236190 · NCI · UNIVERSITY OF MINNESOTA · PI GARCIA, VICTOR ALEXANDER · 2018 to 2021
$143k
NCI NIH HHS F31 CA236190NIGMS NIH HHS R35 GM136309NIH HHS S10 OD021539
6 · The paper itself

Abstract

Multivalency can drive high-avidity binding of ligand-functionalized nanoparticles to cells with high target receptor expression, but it can also contribute to off-target binding to low-expression non-target cells. We explored how ligand affinity and liposome valency shape the resulting binding performance index (BPI), defined as the product of the proportion of liposome-bound target cells and that of non-bound non-target cells. Designed ankyrin repeat proteins (DARPins) spanning a wide range of HER2-binding affinities were tethered onto PEGylated liposomes at varying concentrations. BPI was initially evaluated in mixed-cell suspensions of HER2

Indexed as

Erb-b2 Receptor Tyrosine KinasesLiposomesAnkyrin RepeatFlow CytometryHEK293 CellsHumansNanoparticle Drug Delivery SystemNanoparticlesProtein BindingSurface Plasmon ResonanceErb-b2 Receptor Tyrosine KinasesLiposomesNanoparticle Drug Delivery SystemDARPinsHER2Multivalencynanoparticlesreceptor-targetingselectivity

Identifiers

PMID40548390
PMCPMC12716469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.