Evidence map›Paper›PMID 40548276›Full record

ArticleWorld journal of diabetes2025

Pig bile powder maintains blood glucose homeostasis by promoting glucagon-like peptide-1 secretion

Yi-Min Sun, Jun-Liang Kuang, Hui-Heng Zhang, Xi-Xi Xia, Jie-Yi Wang, Dan Zheng, Ke-Jun Zhou, Ya-Jun Tang, Ai-Hua Zhao, Wei Jia and 2 more

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Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

12 authors.

Yi-Min SunCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Jun-Liang KuangCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Hui-Heng ZhangCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Xi-Xi XiaCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Jie-Yi WangCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Dan ZhengCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Ke-Jun ZhouHuman Metabolomics Institute, Inc., Shenzhen 518109, Guangdong Province, China.
Ya-Jun TangCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Ai-Hua ZhaoCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Wei JiaDepartment of Pharmacology and Pharmacy, University of Hong Kong, Hongkong 999077, China.
Guo-Xiang XieHuman Metabolomics Institute, Inc., Shenzhen 518109, Guangdong Province, China.
Xiao-Jiao ZhengCenter for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. joyzheng99@sjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraditional Chinese medicine offers many valuable remedies for maintaining blood glucose homeostasis in patients with type 2 diabetes mellitus. Bile powder (BP) is a powdered form of bile derived from pigs. It has been used historically in various medicinal applications. Currently, the therapeutic potential of BP in regulating glucose homeostasis remains unclear. Bile acids (BAs) are increasingly recognized for their role in glucose metabolism particularly through the modulation of glucagon-like peptide-1 (GLP-1).

aimTo investigate BP effects on glucose homeostasis and elucidate its mechanistic role through GLP-1 and farnesoid X receptor (FXR) signaling.

methodsA diabetic mouse model was established using a high-fat diet and streptozotocin administration. Mice were treated with BP at doses of 25, 50, or 75 mg/kg/day for 45 days. Glucose homeostasis was assessed

resultsBP treatment significantly improved glucose homeostasis in the diabetic mouse model as indicated by lower blood glucose (

conclusionBP improved glucose homeostasis by promoting GLP-1 secretion

Indexed as

Farnesoid X receptorGlucagon-like peptide 1Pig bile powderTraditional Chinese medicineType 2 diabetes mellitus

Identifiers

PMID40548276
PMCPMC12179914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.