Evidence map›Paper›PMID 40548222›Full record

ArticleWorld journal of methodology2025

Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction.

Emir Bećirović, Minela Bećirović, Sabina Šegalo, Amir Bećirović, Semir Hadžić, Kenana Ljuca, Emsel Papić, Lamija Ferhatbegović, Malik Ejubović, Amira Jagodić Ejubović and 3 more

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Article in World journal of methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Emir BećirovićDepartment of Intensive Care, University Clinical Center Tuzla, Tuzla 75000, Bosnia and Herzegovina.
Minela BećirovićDepartment of Nephrology, University Clinical Center Tuzla, Tuzla 75000, Bosnia and Herzegovina.
Sabina ŠegaloDepartment of Laboratory Technologies, Faculty of Health Sciences, University of Sarajevo, Sarajevo 71000, Bosnia and Herzegovina.
Amir BećirovićDepartment of Endocrinology, University Clinical Center Tuzla, Tuzla 75000, Bosnia and Herzegovina.
Semir HadžićDepartment of Endocrinology, University Clinical Center Tuzla, Tuzla 75000, Bosnia and Herzegovina.
Kenana LjucaSchool of Medicine, University of Tuzla, Tuzla 75000, Bosnia and Herzegovina.
Emsel PapićDepartment of Laboratory Technologies, Faculty of Health Sciences, University of Sarajevo, Sarajevo 71000, Bosnia and Herzegovina.
Lamija FerhatbegovićDepartment for Internal Diseases and Hemodialysis, Canton Hospital Zenica, Zenica 72000, Bosnia and Herzegovina.
Malik EjubovićDepartment of Internal Medicine, Canton Hospital Zenica, Zenica 72000, Bosnia and Herzegovina.
Amira Jagodić EjubovićDepartment of Internal Medicine, Canton Hospital Zenica, Zenica 72000, Bosnia and Herzegovina.
Amila KovčićDepartment of Radiotherapy, University Clinical Center Tuzla, Tuzla 75000, Bosnia and Herzegovina.
Armin ŠljivoDepartment of Cardiology, University Clinical Center Sarajevo, Sarajevo 72000, Bosnia and Herzegovina.
Emir BegagićDepartment of General Medicine, University of Zenica, School of Medicine, Zenica 72000, Bosnia and Herzegovina. begagicem@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-ST segment elevation myocardial infarction (NSTEMI) poses significant challenges in clinical management due to its diverse outcomes. Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care.

aimTo evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events (MACE) in NSTEMI patients, potentially improving clinical outcomes.

methodsA prospective, observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla, Bosnia and Herzegovina. The study included 170 patients with NSTEMI, who were divided into a group with MACE and a control group without MACE. Furthermore, the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis. Alongside hematological parameters, an additional 13 hematological-derived ratios (HDRs) were monitored, and their prognostic role was investigated.

resultsHematological parameters did not significantly differ between non-ST segment elevation myocardial infarction (NSTEMI) patients with MACE and a control group at T1 and T2. However, significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE. Notably, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were elevated in lethal outcomes. Furthermore, C-reactive protein-to-lymphocyte ratio (CRP/Ly) at T1 (> 4.737) demonstrated predictive value [odds ratio (OR): 3.690,

conclusionThis study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients. During follow-up, NLR, PLR, and CRP/Ly offer important insights into the inflammatory processes underlying cardiovascular events.

Indexed as

Hemogram-derived ratiosMyocardial infarctionNeutrophil-to-lymphocyte ratioPrognostic markers

Identifiers

PMID40548222
PMCPMC11612734

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