ArticleFood science & nutrition2025
Enhanced Recovery and Bioactivity of Flavonoids From Peanut Shells (
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Histological Study of Peanut Hull: Initial Barrier Against Fungal Invasion?Plants (Basel, Switzerland) · 2026Article
- Optimization of Ultrasonic Extraction Parameters for Polyphenolic-Rich Extract from Peanut Shells and Its Application in Functional Yogurt.Molecules (Basel, Switzerland) · 2026Article
- The value-added challenge of nuts: antioxidant components, functions and applications in nut by-products.Frontiers in nutrition · 2026Review
- Enhanced Recovery and Bioactivity of Flavonoids From Peanut Shells (Food science & nutrition · 2025Article
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9 authors.
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Abstract
Peanut shells, a by-product of the peanut processing industry, are rich in flavonoid compounds with a range of bioactivities. This study aimed to develop an efficient extraction and fractionation process to enhance the recovery and in vitro antioxidant and acetylcholinesterase (AChE) inhibition activities of these compounds from peanut shells cultivated in Vietnam. Peanut shell samples were subjected to maceration with ethanol, followed by liquid-liquid partitioning (LLP) and column chromatography (CC) using a hexane and ethyl acetate solvent system at varying ratios. This process yielded a crude ethanolic extract (CEE) and its fractions: chloroform (CHF), petroleum ether (PEF), ethyl acetate (EAF), acetone (ACF), and eluted fractions (F1-F4). The developed extraction and fractionation significantly enhanced the total flavonoid content (TFC), from 65.49 mg QE/g in CEE to 759.80 mg QE/g in fraction F2, and quercetin content from 13.46 μg/g (CEE) to 292.38 μg/g (fraction F2). The CEE and its fractions were evaluated for antioxidant activity using a DPPH radical scavenging and AChE inhibitory activity. A strong positive correlation was observed between the TFC and both bioactivities, with activity ranked as follows: F2 > EAF > F3 > F1 > F4 > CHF > PEF > CEE > ACF. Among these samples, fraction F2 demonstrated the highest bioactivities, with IC
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