Evidence map›Paper›PMID 40548188›Full record

ArticleFood science & nutrition2025

Bacteroides, Metabolites, and Lymphocytes: A Triad of Biomarkers in Small Intestinal Bacterial Overgrowth.

Ziteng Wang, Wentao Tan, Lan Wu, Pengfei Zhang, Huanhuan Xiong, Licun Zhu, Jiali Huang, Jianfang Cui, Li Li, Chunmei Guo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ziteng WangGastroenterology Department, Beijing Shijitan Hospital Capital Medical University Beijing China.ORCID https://orcid.org/0000-0002-1543-1933
Wentao TanGastroenterology Department, Beijing Shijitan Hospital Capital Medical University Beijing China.
Lan WuDesign Institute Chinergy Limited Company Beijing China.
Pengfei ZhangEmergency Department, Beijing Tiantan Hospital Capital Medical University Beijing China.
Huanhuan XiongRheumatology and Immunology Department Zhumadian Central Hospital Henan China.
Licun ZhuGastroenterology Department, Shougang Hospital Peking University Beijing China.
Jiali HuangGastroenterology Department, Beijing Shijitan Hospital Capital Medical University Beijing China.
Jianfang CuiGastroenterology Department, Beijing Shijitan Hospital Capital Medical University Beijing China.
Li LiGastroenterology Department, Beijing Shijitan Hospital Capital Medical University Beijing China.
Chunmei GuoGastroenterology Department, Beijing Shijitan Hospital Capital Medical University Beijing China.
Lingling HeGastroenterology Department, Beijing Ditan Hospital Capital Medical University Beijing China.
Hongshan WeiGastroenterology Department, Beijing Ditan Hospital Capital Medical University Beijing China.
Hong LiuGastroenterology Department, Beijing Shijitan Hospital Capital Medical University Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to investigate the clinical characteristics of small intestinal bacterial overgrowth (SIBO) and analyze its relationship with changes in intestinal microbiota and metabolites. The study included patients from Beijing Shijitan Hospital (Feb 2021-Nov 2023) who underwent hydrogen-methane breath tests, hematological tests, and completed questionnaires. Baseline characteristics of SIBO patients were analyzed using descriptive statistics and independent t-tests. Logistic regression and Receiver Operating Characteristic (ROC) curve analysis identified potential SIBO predictors. Chi-square tests assessed the association between SIBO and symptoms. Stool samples from 29 patients underwent 16S rRNA sequencing to analyze gut microbiota and metabolites. Then we explored links between microbiota, metabolites, symptoms, and serum markers. 405 persons in all completed the hydrogen methane breath test, of whom 109 (26.91%) were in the SIBO- and 296 (73.09%) were in the SIBO+. No significant differences were observed between the SIBO+ and SIBO- groups in terms of gender, age, or BMI. However, lymphocyte counts were significantly different between the groups, with lymphocyte count proving to be a better predictor of SIBO in middle-aged and elderly non-obese men. SIBO was significantly associated with diarrhea and acid reflux symptoms. 16S rRNA sequencing of stool samples from 29 patients revealed that

Indexed as

clinical symptomshydrogen methane breath testintestinal floralymphocyte countsmall intestinal bacterial overgrowth

Identifiers

PMID40548188
PMCPMC12181073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.