Evidence map›Paper›PMID 40548131›Full record

ArticleEClinicalMedicine2025

Influence of a six-month home-based individualized physical activity intervention on carotid plaque instability measured by magnetic resonance imaging: a randomized controlled clinical trial.

Mathilde Mura, Emeraude Rivoire, Leila Dehina-Khenniche, Ghina Jazzar, Sophie Schlatter, Nellie Della-Schiava, Matthieu Arsicot, Zahi A Fayad, Patrick Lermusiaux, Anne Long and 5 more

Registry-linked trialAbstract read
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In one paragraph

Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04053166 (Effect of an Individualized Home-based Physical Activity Trial on Carotid Plaque Vulnerability for Asymptomatic Patients), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04053166 nacompletednot on this map

Effect of an Individualized Home-based Physical Activity Trial on Carotid Plaque Vulnerability for Asymptomatic Patients

TypeinterventionalSponsorHospices Civils de LyonRan2019 to 2022Enrolled56ConditionsCarotid AtherosclerosisArmsindividualized home-based physical activity, MRI, blood sampling, Questionnaires, 6-minute walk test
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mathilde MuraUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Emeraude RivoireUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Leila Dehina-KhennicheUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Ghina JazzarUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Sophie SchlatterHigh Fidelity Medical Simulation Center, SIMULYON, Lyon, France.
Nellie Della-SchiavaVascular and Endovascular Surgery Department, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France.
Matthieu ArsicotUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Zahi A FayadBioMedical Engineering and Imaging Institute, Icahn School of Medicine Mount Sinai, New York, NY, USA.
Patrick LermusiauxVascular and Endovascular Surgery Department, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France.
Anne LongUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Philippe DouekRadiology Department, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France.
Erica N ChiricoDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA.
Amandine ThomasUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Vincent PialouxUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.
Antoine MillonUniversity Claude Bernard Lyon 1, LIBM UR 7424, Team Atherosclerosis, Thrombosis and Physical Activity, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Management of asymptomatic patients with carotid atherosclerotic plaque is still debated. Intraplaque haemorrhage measured by magnetic resonance imaging is the best Methods: Findings: Out of 52 patients participating in the trial, 26 were allocated in each arm. The intraplaque haemorrhage score was significantly reduced over time in the physical activity arm (estimate difference: -0.32 ± 0.15, [95% CI -0.63 to -0.01], p = 0.04). The physical activity arm had increased daily step counts at the end of the 6-month intervention compared to the control arm (1843 ± 758, [CI95% 313-3373], p = 0.02). Interpretation: This trial demonstrates that an individualized home-based physical activity intervention could reduce the severity of intraplaque haemorrhage detected by magnetic resonance imaging and that it is feasible in asymptomatic patients with carotid atherosclerotic plaque. These results suggest that this type of moderate-intensity physical activity could be included in this population to the best medical treatment. Funding: This study was funded by the

Indexed as

Cardiovascular diseasesCarotid atherosclerosisConnected devicesIntraplaque haemorrhagemHealthPhysical activity

Identifiers

PMID40548131
PMCPMC12179388

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.