ArticleFrontiers in oncology2025
Primary pancreas NTRK-rearranged neoplasm harboring an EVT6::NTRK3 fusion with a sclerosing epithelioid fibrosarcoma morphology: a case report and comprehensive review of the literature.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
NTRK-rearranged spindle cell neoplasms (NTRK-RSCNs) are an emerging soft tissue tumor entity characterized by NTRK gene fusions, occurring predominantly in the extremities of children and young adults. The diagnosis of this tumor is challenging due to its nonspecific and highly variable morphology. Given the response to selective NTRK inhibitors, it remains critical to identify the rare cases occurring in the viscera of adults. Here, we report a 53-year-old woman who presented with a new abdominal mass of half a month's duration. Magnetic resonance imaging (MRI) showed a mass localized in the body and tail of the pancreas, leading to a partial pancreatectomy. Histologically, the tumor showed that bland monomorphic spindle cells were arranged in single rows of lines along the collagen fiber, reminiscent of sclerosing epithelioid fibrosarcoma. Immunohistochemically, the spindle cells focally expressed CD34 and S100 but lacked SOX10, MUC-4, Desmin, CK, and STAT6 expression. The tumor also showed cytoplasmic reactivity for pan-tyrosine receptor kinase (pan-TRK). Fluorescence
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