Evidence map›Paper›PMID 40547869›Full record

ArticleEvidence-based toxicology2024

A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies.

Gunn E Vist, Heather M R Ames, Gro H Mathisen, Trine Husøy, Camilla Svendsen, Anna Beronius, Emma Di Consiglio, Ingrid L Druwe, Thomas Hartung, Sebastian Hoffmann and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Evidence-based AI: from trailblazer to trustblazer?Frontiers in artificial intelligence · 2026
    Article
  2. Review
  3. Identifying assessment criteria for in vitro studies: a method and item bank.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Gunn E VistNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0001-7764-2501
Heather M R AmesNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0001-8509-7160
Gro H MathisenNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-3824-4898
Trine HusøyNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-2827-7111
Camilla SvendsenNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-3216-0469
Anna BeroniusInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9494-5395
Emma Di ConsiglioEnvironment & Health Department, Italian National Institute of Health (ISS), Rome, Italy.ORCID 0000-0001-5575-0376
Ingrid L DruweUnited States Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessments, Research Triangle Park, NC, USA.ORCID 0000-0002-0591-0295
Thomas HartungCenter for Alternatives to Animal Testing, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-1359-7689
Sebastian HoffmannEvidence-Based Toxicology Collaboration, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-3214-7678
Carlijn R HooijmansDepartment of Anesthesiology, Pain and Palliative Care, Radboud University Medical Centre, Nijmegen, Netherlands.ORCID 0000-0001-6435-5714
Kyriaki MacheraLaboratory of Toxicological Control of Pesticides, Scientific Directorate of Pesticides' Control and Phytopharmacy, Benaki Phytopathological Institute, Kifissia, Greece.ORCID 0000-0001-6499-3468
Pilar PrietoEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.ORCID 0000-0002-9275-6248
Joshua F RobinsonDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0002-2421-4535
Erwin Roggen3Rs Management and Consulting ApS, Lyngby, Denmark.ORCID 0000-0002-9371-8390
Andrew A RooneyDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID 0000-0002-1756-5185
Nicolas RothDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.ORCID 0000-0002-2917-4384
Eliana SpiliotiLaboratory of Toxicological Control of Pesticides, Scientific Directorate of Pesticides' Control and Phytopharmacy, Benaki Phytopathological Institute, Kifissia, Greece.ORCID 0000-0002-0441-7466
Anastasia SpyropoulouLaboratory of Toxicological Control of Pesticides, Scientific Directorate of Pesticides' Control and Phytopharmacy, Benaki Phytopathological Institute, Kifissia, Greece.ORCID 0000-0001-8599-7740
Olga TcheremenskaiaEnvironment & Health Department, Italian National Institute of Health (ISS), Rome, Italy.ORCID 0000-0002-5029-3484
Emanuela TestaiEnvironment & Health Department, Italian National Institute of Health (ISS), Rome, Italy.ORCID 0000-0003-3113-5103
Mathieu VinkenDepartment of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0001-5115-8893
Paul WhaleyNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0003-4021-0785

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

Context: Methods: We derived the item bank from seven literature sources (one existing item bank created from a systematic review of assessment criteria for Results: The item bank contains 405 items of potential relevance to evaluating the internal validity of Discussion: To our knowledge, this is the second item bank of any kind to have been created for toxicology studies, and the first to use focus groups as a data source alongside literature analysis. The large number of items contributed by focus group discussions suggests this is an efficient method for capturing internal validity issues that are not easily identifiable in the literature. We believe our item bank and methodology for its creation will be a useful resource for supporting the development of appraisal tools. Due to the broad applicability of many items in the item bank, it may be informative for study designs beyond the

Indexed as

internal validityIn vitro methodsNAMsrisk of biastoxicology

Identifiers

PMID40547869
PMCPMC12180937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.