Evidence map›Paper›PMID 40547862›Full record

ArticleTherapeutic advances in neurological disorders2025

Sex-based differences in inflammatory predictors of outcomes in patients undergoing mechanical thrombectomy: an inverse probability weighting analysis.

Gabriele Prandin, Matteo Foschi, Mariarosaria Valente, Liqun Zhang, Paresh Malhotra, Simona Sacco, Raffaele Ornello, Francesco Toraldo, Domenico Maisano, Caterina Del Regno and 13 more

Abstract read
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In one paragraph

Article in Therapeutic advances in neurological disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Systemic inflammatory profiles associated with early EEG abnormalities following ischemic stroke: a cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Gabriele PrandinDepartment of Brain Sciences, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-5698-4737
Matteo FoschiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID https://orcid.org/0000-0002-0321-7155
Mariarosaria ValenteStroke Unit, Udine University Hospital, Udine, Italy.
Liqun ZhangDepartment of Neurology, St George's University of London, London, UK.
Paresh MalhotraDepartment of Brain Sciences, Imperial College London, London, UK.
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Raffaele OrnelloDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Francesco ToraldoClinical Neurology, Udine University Hospital and DMED, University of Udine, Udine, Italy.
Domenico MaisanoClinical Neurology, Udine University Hospital and DMED, University of Udine, Udine, Italy.
Caterina Del RegnoClinical Neurology, Udine University Hospital and DMED, University of Udine, Udine, Italy.
Filippo KomauliClinical Neurology, Udine University Hospital and DMED, University of Udine, Udine, Italy.
Adelaida Gartner JarmilloDepartment of Neurology, St George's University of London, London, UK.
Hakam Al-KaradshehDepartment of Neurology, St George's University of London, London, UK.
Hamza ZahidDepartment of Neurology, St George's University of London, London, UK.
Piers KleinDepartment of Neurology, Radiology, Boston Medical Center, Boston, MA, USA.
Mohamad AbdalkaderDepartment of Neurology, Radiology, Boston Medical Center, Boston, MA, USA.
Paolo ManganottiClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste, Trieste, Italy.
Kyriakos LobotesisNeuroradiology, Department of Imaging, Charing Cross Hospital, Imperial College London, NHS Healthcare Trust, London, UK.
Thanh N NguyenDepartment of Neurology, Radiology, Boston Medical Center, Boston, MA, USA.
Gian Luigi GigliStroke Unit, Udine University Hospital, Udine, Italy.
Soma BanerjeeDepartment of Brain Sciences, Imperial College London, London, UK.
Giovanni MerlinoStroke Unit, Udine University Hospital, Udine, Italy.
Lucio D'AnnaDepartment of Brain Sciences, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inflammatory biomarkers, key predictors of ischemic stroke prognosis, may exhibit sex-specific predictive patterns. Objectives: This study investigates sex-based differences in inflammatory biomarkers as predictors of 90-day clinical outcomes in acute ischemic stroke patients undergoing mechanical thrombectomy (MT). Design: Multicenter retrospective study. Methods: This study included 970 patients consecutively treated with MT for anterior circulation large vessel occlusion between 2016 and 2023. Inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP), systemic inflammation response index, and systemic immune-inflammation index, were measured on admission and 24-h post-MT. Inverse probability weighting was used to balance baseline characteristics between male and female patients. Least absolute shrinkage and selection operator regression and logistic regression were used to identify independent predictors of 90-day good functional outcomes (modified Rankin scale (mRS) score 0-2) and death, stratified by sex and age groups (<55 and ⩾55 years). Results: In the male weighted population (516 patients), multivariable analysis showed that MLR (odds ratio (OR): 0.37, 95% confidence interval (CI): 0.13-0.95, Conclusion: This study highlights sex-based differences in the predictive value of widely available inflammatory biomarkers for stroke outcomes. MLR was a distinct predictor in men, while CRP was uniquely associated with outcomes in women. These findings underscore the need for sex-stratified approaches in stroke management and research.

Indexed as

inflammatory markerssexthrombectomy

Identifiers

PMID40547862
PMCPMC12182613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.