Evidence map›Paper›PMID 40547817›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2025

Carbohydrate-Deficient Transferrin Evaluation Over Time Has Usefulness for Confirming Sobriety of Alcohol Rehabilitation Program Patients.

Noriyo Yamashiki, Miki Murata, Shunichiro Ikeda, Kazushi Sugimoto, Akiko Eguchi, Motoh Iwasa, Saeko Nagao, Kanehiko Suwa, Toshihito Seki, Makoto Naganuma

Abstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noriyo YamashikiDepartment of Gastroenterology and Hepatology Kansai Medical University Medical Center Osaka Japan.ORCID https://orcid.org/0000-0002-9274-0000
Miki MurataDepartment of Gastroenterology and Hepatology Kansai Medical University Medical Center Osaka Japan.
Shunichiro IkedaDepartment of Neuropsychiatry Kansai Medical University Osaka Japan.
Kazushi SugimotoDepartment of Gastroenterology and Hepatology Mie University Graduate School of Medicine Tsu Japan.
Akiko EguchiDepartment of Gastroenterology and Hepatology Mie University Graduate School of Medicine Tsu Japan.ORCID https://orcid.org/0000-0002-0555-2707
Motoh IwasaDepartment of Gastroenterology and Hepatology Mie University Graduate School of Medicine Tsu Japan.
Saeko NagaoKure Midorigaoka Hospital Hiroshima Japan.
Kanehiko SuwaDepartment of Gastroenterology and Hepatology Kansai Medical University Medical Center Osaka Japan.
Toshihito SekiDepartment of Gastroenterology and Hepatology Kansai Medical University Osaka Japan.
Makoto NaganumaDepartment of Gastroenterology and Hepatology Kansai Medical University Osaka Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: For treating severe alcohol-related liver disease (ALD), abstinence from alcohol is essential. Because underreporting can occur, abstinence biomarkers are necessary during hepatology outpatient service. This study assesses whether serial changes of the serum carbohydrate-deficient transferrin to transferrin ratio (%CDT) reflect patient abstinence. Methods: We retrospectively investigated serial %CDT measurements and laboratory data from two outpatient settings: patients in an alcohol rehabilitation program (A), and ALD patients at a hepatology clinic (H) who attempted abstinence with self-diary monitoring. Using group A data, correlation coefficients were determined between the number of days from the last drink (abstinence days) and laboratory data. Linear approximation was applied for significant coefficients. Using these results, %CDT was validated for group H. Results: Group A data were 223 data samples from 55 cases with abstinence days. Four (7%) were diagnosed as having cirrhosis. Eighteen patients continued abstinence over 30 days. %CDT ( Conclusion: The %CDT trend assessment is useful to support continued, multi-month self-reported abstinence from alcohol, but it must be interpreted carefully in severe liver disorder cases.

Indexed as

alcohol use disorderambulatory careliver cirrhosis

Identifiers

PMID40547817
PMCPMC12179798

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.