Evidence map›Paper›PMID 40547719›Full record

ArticleJournal of family medicine and primary care2025

An observational study of clinical profile and EEG changes in patients with metabolic encephalopathy.

Ajay K Mishra, Shahenshah Ahmad, Mahima Pandey, Saboor Mateen, Firdaus Jabeen, Nazrul Haque, Memon Z Abubakkar, Furqan A Memon

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Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Ajay K MishraDepartment of General Medicine, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Shahenshah AhmadDepartment of General Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Mahima PandeyDepartment of General Medicine, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Saboor MateenDepartment of General Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Firdaus JabeenDepartment of General Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Nazrul HaqueDepartment of General Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Memon Z AbubakkarDepartment of General Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Furqan A MemonDepartment of General Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To assess the clinical profile and electroencephalography (EEG) abnormal patterns in patients with metabolic encephalopathy (ME). Methods: A cross-sectional observational study was conducted on 80 diagnosed patients of ME over a period of 24 months from January 2019 until January 2021. Causes of ME were determined. Glasgow coma score (GCS) was recorded. Routine biochemical investigations were done, and EEG patterns were recorded. The outcome measures were association of EEG patterns with the cause of ME. Results: The mean age was 39.62 ± 14.98 years, with 61.3% being men. The mean GCS was 13.28 ± 0.96. The cause of ME was single in 34 (42.5%) cases and multifactorial in 46 (57.5%) cases. Hyperammonemia was present in all patients. Abnormal EEG findings were observed in 7 (8.75%) patients in the form of slow posterior background rhythm. The patients with normal EEG had comparable mean GCS as those with abnormal EEG (13.30 ± 0.97 vs. 13.14 ± 0.90, Conclusion: ME is seen in a wide age group of patients with majority being in the age group of 21 to 40 years followed by 41 to 60 years. It carries a male predominance with multifactorial causes where hyperammonemia remains the most common metabolic abnormality. Cases may either have a single cause or multiple causes for metabolic abnormality. EEG abnormality was seen in only 8.7% cases with no statistical relation with causes of metabolic abnormality.

Indexed as

ElectroencephalographyGlasgow coma scalemetabolic encephalopathy

Identifiers

PMID40547719
PMCPMC12178493

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