Evidence map›Paper›PMID 40547704›Full record

ArticleACS omega2025

Cathy A Muste, Thomas C Pickel, Philippe N Bolduc, Emily A Peterson, Chungang Gu, Brendon E Cook

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Small-Molecule Activation of mRNA Translation by Click-to-Release Reaction in Cells.Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cathy A MusteDrug Metabolism and Pharmacokinetics, Biogen, Cambridge, Massachusetts 02142, United States.ORCID https://orcid.org/0000-0002-9246-8449
Thomas C PickelASO Development, Biogen, Cambridge, Massachusetts 02142, United States.
Philippe N BolducMedicinal Chemistry, Biogen, Cambridge, Massachusetts 02142, United States.
Emily A PetersonMedicinal Chemistry, Biogen, Cambridge, Massachusetts 02142, United States.
Chungang GuDrug Metabolism and Pharmacokinetics, Biogen, Cambridge, Massachusetts 02142, United States.ORCID https://orcid.org/0009-0007-9386-2003
Brendon E CookBiomarkers, Biogen, Cambridge, Massachusetts 02142, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PET imaging of intrathecally dosed ASO neurology drugs is challenging due to the long time needed to achieve steady-state brain distribution, making the use of a simple

Identifiers

PMID40547704
PMCPMC12177633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.