ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Associations of abdominal adiposity, lean body mass, and fat body mass with dementia and cognitive change in older age.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Skeletal muscle fatigue resistance is differentially affected in 8-month-old male and female hAβ-KI mice.Physiological reports · 2026Article
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Association Between Relative Fat Mass and Risk of Cognitive Impairment: The Role of Social Determinants of Health.Actas espanolas de psiquiatria · 2026Article
- Weight-adjusted-waist index, inflammation, and cognitive performance in older adults: a cross-sectional analysis from the Hordaland Health Study.Frontiers in aging · 2026Article
- Associations Between Serum Selenium, Zinc, and Copper Levels and Cognitive Function in the Elderly.Nutrients · 2025Article
- Associations of abdominal adiposity, lean body mass, and fat body mass with dementia and cognitive change in older age.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
10 authors.
Funding
Abstract
introductionThis study examined whether the waist circumference-body mass index ratio (WBR), lean body mass (LBM), and fat body mass (FBM) were associated with dementia or cognitive change.
methodsWe analyzed data from >17,000 individuals aged 65 to 98 years at enrollment. LBM and FBM were estimated using the Hume equation. Dementia was determined according to DSM-IV. Global cognition, verbal fluency, episodic memory, and psychomotor speed were assessed across 11 years. Cox and mixed-effects models were used to examine the associations with dementia and cognitive change.
resultsWBR was positively associated with dementia (Q4 versus Q1, hazard ratio [HR]: 1.29, DISCUSSION: Higher LBM and FBM in later life may be associated with better cognition, while abdominal fat could be a risk factor. Highligths: Higher WBR is associated with greater dementia risk, only in men.Higher WBR is associated with faster cognitive decline.Greater LBM and FBM are associated with lower dementia risk.Greater LBM and FBM are associated with slower cognitive decline.Central adiposity may be a risk factor for cognitive impairment in older adults.
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