Evidence map›Paper›PMID 40547529›Full record

ArticleFrontiers in endocrinology2025

The burden of polycystic ovary syndrome-related infertility in 204 countries and territories, 1990-2021: an analysis of the global burden of disease study 2021.

Lan Zheng, Xiao Xu, Jin-Zhuo Zhou, Lin Hong, Yu-Feng He, Ya-Xing Fang, Bing-Bing Wang, Hui Chen, Kang-Jia Chen, Su-Su Yang and 3 more

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lan Zheng *Department of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Xiao Xu *Department of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Jin-Zhuo Zhou *Department of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Lin HongDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Yu-Feng HeDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Ya-Xing FangDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Bing-Bing WangDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Hui ChenDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Kang-Jia ChenDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Su-Su YangDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Xiao-Long YangDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.
Hai-Feng PanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China.
Shu-Guang ZhouDepartment of Gynecology, Maternal and Child Health Center of Anhui Medical University, The Fifth Affiliated Clinical College of Anhui Medical University, Anhui Women and Children's Medical Center, Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The evolving patterns of the infertility attributed to polycystic ovary syndrome (PCOS) disease burden are being evaluated, stratified by age, region, subtype, and health condition. Material and methods: This cross-sectional investigation encompassed data from 21 regions and 204 countries from 1990 to 2021, sourced through the Institute for Health Metrics and Evaluation. The prevalence and YLDs due to infertility, overall and stratified by age, subtype, region, country, and health status. The percent change in age-standardized rates (ASR) was calculated to temporal quantify the trend of infertility burden. The Bayesian age-period-cohort (BAPC) model was employed to forecast the trends in the ASR of prevalence and YLD from 2022 to 2042. Results: Globally, the age-standardized prevalence and YLDs in infertility attributed to PCOS showed a significant increase trend from 1990 to 2021, with ASR of 34.2% (95%CI: 28.2 to 41.5%) and 32.5% (95%CI: 26.6 to 39.4%), respectively. The spatiotemporal trends in infertility attributed to PCOS varied substantially between subtypes and age groups. The burden of primary infertility peaked among individuals aged 20 to 24 years, whereas secondary infertility consistently peaked among individuals aged 35 to 44 years. The BAPC model showed that the burden of infertility will increase over the next 2 decades. Conclusions: Infertility attributed to PCOS remains to be a significant public health issue globally, with this burden varying considerably across age groups, and subtypes. Decision-makers providers must take a proactive stance in monitoring developing trends and adapting infertility screening and management protocols to different age brackets and subtypes.

Indexed as

Global Burden of DiseaseInfertility, FemalePolycystic Ovary SyndromeAdultCost of IllnessCross-Sectional StudiesFemaleGlobal HealthHumansMiddle AgedPrevalenceYoung Adultinfertility attributed to PCOSprevalencethe bayesian age-period-cohort modelthe global burden of disease studyyears lived with disability rates

Identifiers

PMID40547529
PMCPMC12178856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.