Evidence map›Paper›PMID 40547526›Full record

ArticleFrontiers in endocrinology2025

The association between pancreatic diseases and pancreatic fat content: a cross-sectional study from the UK Biobank.

Jing Gao, Xiaowu Dong, Xiaolei Shi, Yuqing Yang, Weiwei Chen, Weiming Xiao, Guotao Lu, Xiaoping Yu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing Gao *Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Xiaowu Dong *Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Xiaolei Shi *Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Yuqing YangSchool of Nursing, School of Public Health, Yangzhou University, Yangzhou, China.
Weiwei ChenClinical Medical College, Yangzhou University, Yangzhou, China.
Weiming XiaoPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Guotao LuPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Xiaoping YuDepartment of Health Management Center, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Many researches have demonstrated an association between intra-pancreatic fat deposition (IPFD) and several pancreatic pathological conditions, including pancreatitis, pancreatic cancer, and type 2 diabetes mellitus (T2DM). The aim of this study is to investigate the influence of pancreatic diseases on the accumulation of pancreatic fat, to further explore which kind of pancreatic disease is significant, and to find out the possible mediating factors. Methods: A cross-sectional study based on the UK Biobank (UKB) data categorized participants by pancreatic disease status and collated relevant information. IPFD was measured using MRI in combination with a deep learning-based organ segmentation model, nnUNet. Linear regression models and mediation analysis were employed to explore the association between pancreatic diseases and IPFD. Results: Among 61,088 participants, those with pancreatic diseases exhibited higher IPFD than those without (pancreatic endocrine diseases: 11.72% Conclusion: Pancreatic exocrine disorders are not associated with an increased risk of IPFD, whereas pancreatic endocrine disorders, particularly T2DM, may exhibit a positive relationship. However, the possibility of reverse causation cannot be discounted.

Indexed as

Adipose TissuePancreasPancreatic DiseasesAdultAgedBiological Specimen BanksCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansMagnetic Resonance ImagingMaleMiddle AgedUK BiobankUnited Kingdomintra-pancreatic fat depositionmediation analysispancreatic diseasestype 2 diabetes mellitusUK Biobank

Identifiers

PMID40547526
PMCPMC12178842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.