ArticleJournal of experimental pharmacology2025
Article in Journal of experimental pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Fermentation-Induced Changes in Phytochemical Composition and Pharmacological Activities ofDrug design, development and therapy · 2026Review
- Medicinal Plants That Modulate Nitric Oxide Synthase Activity: Implications in Inflammation and Oxidative Stress.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ethanol consumption by oral route can induce gastric cell necrosis and vascular damage due to excessive reactive oxygen species (ROS) production. ROS activates the translocation of NF-κB to the nucleus and increases iNOS expression, an enzyme that catalyzes nitric oxide (NO) production, eventually disrupting gastric protective mechanisms and contributing to ulcer formation. Purpose: To confirm the gastro-protective and anti-ulcer effects of the Methods: The fresh inflorescence petals were collected from West Java, Indonesia, and were extracted using 70% ethanol. The effects of 5 days of oral administration of EEIE were studied in ethanol-induced adult male Wistar rats by examining the weight gain percentage, feed residue, stomach ratio index, and microscopic and macroscopic evaluation of gastric mucosal damage. Subsequently, the iNOS expression in the rats' stomach was Western blotted by employing β-actin as the loading control. Results: EEIE reduced weight gain percentage but did not show a significant difference in feed residue. EEIE increased the stomach ratio index, and at a dose of 625 mg/kg BW, significantly reduced the ulcer index, providing 100% protection (p < 0.05) to rats while decreasing inflammatory cell infiltration. EEIE inhibited the expression of iNOS in both cleaved and full-length forms at this dose. Conclusion:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.