ArticleFrontiers in molecular neuroscience2025
Non-invasive biomarkers for brain aging: the role of autophagy-related microRNAs in plasma exosomes.
Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparison of multi-miRNA models from donor-matched plasma and cerebrospinal fluid as candidate biomarkers for Alzheimer's disease prediction.Scientific reports · 2025Article
- Computational Splicing Analysis of Transcriptomic Data Reveals Sulforaphane Modulation of Alternative mRNA Splicing of DNA Repair Genes in Differentiated SH-SY5Y Neurons.International journal of molecular sciences · 2025Article
- Review
- MicroRNAs as Regulators of Neuroinflammation in Major Depressive Disorder.Depression and anxiety · 2025Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: This study aimed to identify autophagy-related microRNAs (miRNAs) in plasma exosomes as non-invasive biomarkers for brain aging and explore their potential to improve early detection of age-associated neurodegeneration. With the increasing incidence of neurodegenerative disorders, such as Alzheimer's disease (AD), frontotemporal dementia (FTD), and Parkinson's disease (PD), non-invasive diagnostic tools are urgently needed. Methods: Plasma samples were collected from 200 individuals, divided into three groups, including young (20-40 years), middle-aged (41-60 years), and elderly (> 60 years). Exosomes were isolated, followed by small RNA sequencing (sRNA-seq) to identify differentially expressed miRNAs, and differentially expressed miRNAs related to autophagy were validated using quantitative real-time PCR (qRT-PCR). Spearman correlation analysis was performed to assess the relationship between autophagy-related miRNAs and brain aging biomarkers. Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic performance. Results: Nine autophagy-related miRNAs were identified and validated as significantly upregulated in plasma exosomal from elderly, including hsa-miR-2110, hsa-miR-18a-3p, hsa-miR-766-3p, hsa-miR-4446-3p, hsa-miR-4667-5p, hsa-miR-4433b-3p, hsa-miR-146a-5p, hsa-miR-423-5p, and novel_260. These miRNAs were validated by qRT-PCR. Correlation analysis showed that several of these miRNAs, such as hsa-miR-2110 and hsa-miR-766-3p, were strongly correlated with NfL ( Conclusion: This study identifies a set of autophagy-related miRNAs as promising biomarkers for brain aging. The combination of these miRNAs with traditional biomarkers offers a non-invasive and highly sensitive method for early detection of brain aging, providing significant potential to enhance diagnostic accuracy in neurodegenerative diseases.
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