ArticleEClinicalMedicine2025
Balancing the benefits and risks of colchicine use among patients with atherosclerotic cardiovascular disease: an umbrella review of meta-analyses of randomised controlled trials.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Metabolic Reprogramming-Driven Cardiovascular Immune Damage: From Glyco-Lipotoxicity and Epigenetic Memory to Multidimensional Cross-Organ Communication Networks.International journal of molecular sciences · 2026Review
- Mechanisms and therapeutic potential of colchicine in atherosclerotic cardiovascular disease.Nature cardiovascular research · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The risks and benefits of colchicine use among patients with atherosclerotic cardiovascular disease (ASCVD) have been widely reported. Our umbrella review aimed to systematically analyse and synthesise the available causal evidence on the therapeutic effects and safety profile of colchicine in patients with ASCVD. Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library from database inception to December 4, 2024, to identify systematic reviews and meta-analyses of randomised controlled trials (RCTs) investigating colchicine use among patients with ASCVD. The primary endpoints were physical adverse events, MACEs, and CV disorder. The quality of systematic reviews was evaluated using A Measurement Tool to Assess Systematic Reviews (AMSTAR), and the certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system. Risk of bias was evaluated using Cochrane Systematic Review criteria. Inconsistency was flagged if heterogeneity ( Findings: This review analysed 47 unique outcomes from 48 systematic reviews and meta-analyses of RCTs. Among 271 associations, 95 were supported by high-certainty evidence. For primary outcomes, compared with placebo treatment, colchicine exhibited therapeutic efficacy in coronary heart disease [relative risk (RR): 0.73, 95% confidence interval (CI): 0.64-0.83, Interpretation: High-certainty evidence supported the therapeutic and secondary preventive benefits of colchicine in patients with ASCVD when dose and duration were appropriately controlled. Future studies could focus on identifying ASCVD subgroups with pharmacogenomic and ethnographic predictors of colchicine response heterogeneity to guide precision therapy. Funding: This work was supported by the Liaoning Revitalization Talents Program, Outstanding Youth Scientific Talent Project of Dalian, and Outstanding Scientific Fund of Shengjing Hospital.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.