Evidence map›Paper›PMID 40547330›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)

System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment.

B Joy Snider, Alessandro Biffi, Sasha Bozeat, Carolyn Clevenger, Gill Farrar, Darren Gitelman, Rachel Kolster, Soeren Mattke, Michelle Mielke, Debjani Mukherjee and 10 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The value of timely treatment with anti-amyloid therapy for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

B Joy SniderDepartment of Neurology Washington University School of Medicine St. Louis Missouri USA.
Alessandro BiffiEli Lilly and Company Indianapolis Indiana USA.
Sasha BozeatF. Hoffman-La Roche AG Basel Switzerland.
Carolyn ClevengerNell Hodgson Woodruff School of Nursing Emory University Atlanta Georgia USA.
Gill FarrarGE HealthCare Buckinghamshire UK.
Darren GitelmanAdvocate Memory Center Advocate Lutheran General Hospital Chicago Illinois USA.
Rachel KolsterThe Janssen Pharmaceutical Companies of Johnson & Johnson Titusville New Jersey USA.
Soeren MattkeThe USC Brain Health Observatory USC Dornsife Los Angeles California USA.
Michelle MielkeDivision of Public Health Sciences Wake Forest University School of Medicine Winston-Salem North Carolina USA.
Debjani MukherjeePharmaceutical Care Management Association Washington District of Columbia USA.
Jennifer MurphyBiogen Neurodegeneration Unit Cambridge Massachusetts USA.
Hamid OkhraviDepartment of Medicine: Glennan Center for Geriatrics and Gerontology Eastern Virginia Medical School Norfolk Virginia USA.
Gil D RabinoviciMemory & Aging Center Departments of Neurology Radiology & Biomedical Imaging, University of California San Francisco San Francisco California USA.
Dorene RentzHarvard Medical School Brigham and Women's Hospital Boston Massachusetts USA.
Jose SoriaUniversity of California San Diego Health San Diego California USA.
Heather SynderAlzheimer's Association Chicago Illinois USA.
Gregg WalkerAlzheimer's Association Chicago Illinois USA.
Simin MahinradAlzheimer's Association Chicago Illinois USA.
Maria C CarrilloAlzheimer's Association Chicago Illinois USA.
Christopher J WeberAlzheimer's Association Chicago Illinois USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promising therapeutic interventions that target the underlying pathophysiology are changing the landscape of Alzheimer's disease (AD) research. The AD care pathway must be transformed to meet the challenge of bringing these new therapies to the increasing number of people living with AD within the existing healthcare framework. Challenges include identifying patients who may benefit from treatment interventions early in the course of the disease, ensuring that diagnostic tools are accessible and accurate, and developing capabilities to monitor the effectiveness of interventions over time. These challenges must be addressed at all levels, from primary care settings to tertiary treatment centers; this will require collaborative efforts between health systems, drug manufacturers, and research institutions to navigate this evolving landscape and ensure system readiness for patients and their families with AD. The Spring 2024 Alzheimer's Association Research Roundtable (AARR) meeting gathered industry representatives and clinicians to discuss insights, challenges, and solutions that will help researchers and health systems identify patients in the early stages of AD and deliver emerging therapies efficiently and safely. In this paper, we provide highlights from the Spring 2024 AARR meeting.

Indexed as

Alzheimer's diseaseamyloidbiomarkerscognitive testingdiagnosticsdisease‐modifying therapyearly diagnosisearly interventionhealth systemsreal world datareimbursementsystem readinesstreatments

Identifiers

PMID40547330
PMCPMC12178942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.