Evidence map›Paper›PMID 40547329›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)

Claire J Cadwallader, Anna M VandeBunte, D Luke Fischer, Coty Chen, Valentina E Diaz, Shannon Y Lee, Brandon Chan, Argentina Lario-Lago, Julio C Rojas, Eliana Marisa Ramos and 6 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Alzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Claire J CadwalladerDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.ORCID https://orcid.org/0000-0003-3449-3803
Anna M VandeBunteDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
D Luke FischerDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Coty ChenDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Valentina E DiazDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Shannon Y LeeDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Brandon ChanDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Argentina Lario-LagoDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Julio C RojasDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Eliana Marisa RamosDepartment of Neurology David Geffen School of Medicine University of California Los Angeles USA.
Jessica E RexachDepartment of Neurology David Geffen School of Medicine University of California Los Angeles USA.
Jennifer S YokoyamaDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Joel H KramerDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Emily W PaolilloDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Rowan SalonerDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.
Kaitlin B CasalettoDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI HELENA Chang CHUI, Gyungah Jun · 2023 to 2026
$39.4M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal ProteasesU54NS123985 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A., KAO, AIMEE · 2021 to 2025
$9.0M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Unraveling the intersection of synaptic biology, lifestyle, and cognitive resilienceR01AG072475 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2021 to 2025
$4.3M
Elucidating clinical heterogeneity in early-onset AD via genomics, transcriptomics, and neuroimagingR01AG062588 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOKOYAMA, JENNIFER S · 2019 to 2023
$4.0M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)UE5NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Scott Andrew Josephson · 2024 to 2026
$2.6M
NIA NIH HHS K23 AG058752NIA NIH HHS K23 AG084883NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG062588NIA NIH HHS R01 AG072475NIA NIH HHS T32 AG023481NIA NIH HHS U19 AG079774NIDA NIH HHS 75N95022C00031NINDS NIH HHS K08 NS105916NINDS NIH HHS R25 NS070680NINDS NIH HHS U54 NS123985NINDS NIH HHS UE5 NS070680NINDS NIH HHS UF1 NS100608
6 · The paper itself

Abstract

introductionIncreased brain-derived neurotrophic factor (BDNF) release through physical activity (PA) is thought to underlie protective effects of PA on brain aging. The

methodsOne hundred eighty older adults (M

resultsDISCUSSION: The Val/Val Highlights: Higher physical activity (PA) is associated with lower phosphorylated tau (p-tau181) in brain-derived neurotrophic factor (

Indexed as

Alzheimer's diseaseBDNF Val66Met single‐nucleotide polymorphismcognitionGFAPhealthy agingphysical activityplasma biomarkersp‐tau 181Rs6265sex differences

Identifiers

PMID40547329
PMCPMC12178939

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.