Evidence map›Paper›PMID 40547322›Full record

ArticleBioactive materials2025

One-step strategy for fabricating icariin-encapsulated biomimetic Scaffold: Orchestrating immune, angiogenic, and osteogenic cascade for enhanced bone regeneration.

Fengxin Zhao, Fuying Chen, Tao Song, Luoqiang Tian, Hang Guo, Dongxiao Li, Jirong Yang, Kai Zhang, Yumei Xiao, Xingdong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fengxin ZhaoNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.
Fuying ChenNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.
Tao SongNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.
Luoqiang TianNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.
Hang GuoNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.
Dongxiao LiSichuan Academy of Chinese Medicine Science, Chengdu, Sichuan, 610042, China.
Jirong YangResearch Center for Human Tissue and Organs Degeneration, Institute of Biomedical and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Kai ZhangNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.
Yumei XiaoNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.
Xingdong ZhangNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Research Center for Material Genome Engineering, Sichuan University, Chengdu, 610065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repair of bone defects relies on the intricate coordination of inflammation, angiogenesis, and osteogenesis. However, scaffolds capable of integrating osteo-immunomodulation and vascular-bone coupling to cascade-activate these processes remain a challenge. Here, a biomimetic scaffold (CHP@IC) with

Indexed as

Biomimetic scaffoldBone regenerationCascade activationIcariin deliveryOne-step strategy

Identifiers

PMID40547322
PMCPMC12182316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.