Evidence map›Paper›PMID 40547261›Full record

ArticleRSC medicinal chemistry2025

Synergistic effect of the hybrid compounds of cationic pillararene and an efflux pump inhibitor against Gram-negative bacteria.

Yisu Liu, Guangpu Wu, Jiang Zhu, Yao Jiang, Hui Liu

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yisu LiuKey Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology 693 Xiongchu Avenue Wuhan 430073 P. R. China huiliu@wit.edu.cn.
Guangpu WuKey Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology 693 Xiongchu Avenue Wuhan 430073 P. R. China huiliu@wit.edu.cn.
Jiang ZhuMedical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical College Nanchong 637000 Sichuan P. R. China.ORCID https://orcid.org/0000-0001-7437-2956
Yao JiangDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College Nanchong 637000 Sichuan P. R. China.
Hui LiuKey Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology 693 Xiongchu Avenue Wuhan 430073 P. R. China huiliu@wit.edu.cn.ORCID https://orcid.org/0000-0001-5140-7618

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel antibiofilm agents were designed by integrating cationic pillararene with an efflux pump inhibitor. The hybrid compounds were prepared and characterized using NMR and HRMS. These compounds exhibited potent activity to inhibit biofilm formation and disrupt the outer membrane in Gram-negative bacteria. In addition, the synergistic effect of the hybrid compounds was observed in combination with antibiotics, especially against

Identifiers

PMID40547261
PMCPMC12178264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.