Evidence map›Paper›PMID 40547247›Full record

ArticleWorld journal of orthopedics2025

Effect of blood flow restriction on muscle strength and stability following foot and ankle injury: A systematic review.

Julia M Balboni, Karthik Madhira, Victor Martinez, Wei-Shao Tung, John G Kennedy, Arianna L Gianakos

Abstract read
In one paragraph

Article in World journal of orthopedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Julia M BalboniDepartment of Orthopaedic Surgery, University of New England College of Osteopathic Medicine, Biddeford, ME 04005, United States. jbalboni@une.edu.
Karthik MadhiraDepartment of Orthopaedics, New York Institute of Technology College of Osteopathic Medicine, Glen Head, NY 11545, United States.
Victor MartinezDepartment of Orthopedic Surgery, University of Texas Health San Antonio, San Antonio, TX 78229, United States.
Wei-Shao TungDepartment of Orthopaedics, Massachusetts General Hospital, Boston, MA 02114, United States.
John G KennedyDepartment of Orthopedic Surgery, NYU Langone Health, New York, NY 10002, United States.
Arianna L GianakosDepartment of Orthopaedic Surgery, Yale University School of Medicine, New Haven, CT 06510, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor musculoskeletal recovery following foot and ankle injury can result in chronic instability and persistent muscle weakness. Preliminary evidence has shown that blood flow restriction (BFR) rehabilitation can increase muscle strength and stability, helping to restore physical function and prevent repeated injury.

aimTo determine whether BFR is more effective than traditional rehabilitation in improving muscle strength, size, and stability after foot and ankle injury.

methodsA systematic review and meta-analysis were performed. Articles were retrieved from MEDLINE, EMBASE, and CENTRAL databases. Included studies compared the effectiveness of BFR rehabilitation to traditional foot and ankle rehabilitation exercises. Eligible patients were those with a history of foot or ankle injury. Muscle strength, size, and dynamic balance were assessed by comparing improvements in peak torque, cross-sectional area, and percent muscle activation. Methodological quality assessments were performed using the PEDro scale and Methodological Index for Non-Randomized Studies (MINORS).

resultsTen studies met the inclusion criteria. Five studies were of good to excellent quality according to the PEDro scale, and 5 studies were of moderate quality as per the MINORS criteria. Two studies compared the effect of BFR and non-BFR rehabilitation on muscle strength; the overall mean difference between the BRF and non-BFR groups was 0.09 [95%CI: (0.05, 0.12),

conclusionBFR rehabilitation is more effective than non-BFR rehabilitation at improving muscle strength and activation following foot and ankle injury. Additional studies are needed to develop a standardized BFR training protocol.

Indexed as

Ankle fractureBlood flow restrictionChronic ankle instabilityMuscle activationMuscle hypertrophyMusculoskeletal rehabilitation

Identifiers

PMID40547247
PMCPMC12179901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.