ReviewFrontiers in psychiatry2025
Adult ADHD and comorbid anxiety and depressive disorders: a review of etiology and treatment.
Review in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- ADHD Symptoms in Parents of Children With or Without ADHD: Prospective Association With Children's Quality of Life and Emotional and Conduct Problems (EPINED Cohort).Research on child and adolescent psychopathology · 2026Article
- Childhood ADHD and Its Adult Mimics: When First-Time ADHD Diagnoses in Adulthood May Reflect Other Conditions-A Narrative Review.Brain sciences · 2026Review
- What Provider Frequently Asked Questions Miss: Evaluating Unmet Attention-Deficit/Hyperactivity Disorder Information Needs Through Comparison of Online Community Posts Using Large Language Model-Assisted Semantic Analysis in a Mixed Methods Study.Journal of medical Internet research · 2026Article
- Effectiveness of psychological therapies for depression and anxiety in adults with and without ADHD in England: a retrospective cohort study.The Lancet regional health. Europe · 2026Article
- Patterns of Lateral Frontal Delta Asymmetry in Adult Attention-deficit/Hyperactivity Disorder with Comorbid Depression: A Quantitative Electroencephalography Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Associations Between Sleep-Related Characteristics and Mind Wandering in Adults with ADHD: A Cross-Sectional Study with a Control Group.Behavioral sciences (Basel, Switzerland) · 2026Article
- Pharmacokinetics at Different Application Sites and Dermal Safety Analysis of Dextroamphetamine Transdermal System (d-ATS) in Healthy Adults and Patients with ADHD.Advances in therapy · 2026Article
- Emotional Profiles in Adolescents With ADHD: A Person-Centered Analysis of Emotion Regulation, Resilience, and Internalizing Symptoms.Alpha psychiatry · 2026Article
- The diagnostic validity of central symptoms for major depressive disorder in adults with attention-deficit/hyperactivity disorder: a network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Associations of Anxiety and Depression and Hypomanic Traits with Self-Informant Discrepancies in Adults First Diagnosed with ADHD in Adulthood: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- The spectrum of neurodevelopmental disorders: comorbidities as clues to pathogenesis.Current opinion in psychiatry · 2026Review
- Developing the Link-me+EMPHN Mental Health Model of Care to Improve General Practitioner Capacity for Mental Health Care in Australian Primary Care: Protocol for a Mixed Methods Formative Study.JMIR research protocols · 2026Article
- High functioning, yet high suffering - the need to incorporate invisible struggles in adult ADHD diagnostic assessment/criteria.Frontiers in psychiatry · 2026Article
- Intersecting trajectories of childhood ADHD, socioeconomic deprivation and distinct multimorbidity patterns in women.Nature. Mental health · 2026Article
- Article
- The indirect pathway hypothesis of schizophrenia: insights from perinatal asphyxia.Frontiers in physiology · 2026Review
- Validation of a criterion-based screening and triage pathway for adult ADHD: a prospective observational study of safety and operational efficiency.Frontiers in psychiatry · 2026Article
- Closed-loop acoustic stimulation modified by cathodal tDCS is beneficial for retention.bioRxiv : the preprint server for biology · 2025Article
- ADHD in Adulthood: Clinical Presentation, Comorbidities, and Treatment Perspectives.International journal of molecular sciences · 2025Review
- Caffeine consumption and behavioral symptoms: influence of ADORA2A and DRD2 genes on inattention.European journal of nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: ADHD, or Attention-Deficit/Hyperactivity Disorder, is a neurodevelopmental disorder that is known for its high degree of heterogeneity. It often coexists with other psychiatric diseases, especially anxiety and depression. This article reviews recent studies to explore the etiology of comorbid anxiety and depressive disorders in adults with ADHD, analyzing the factors contributing to this elevated comorbidity rate from several perspectives. Additionally, we explore potential directions for future research in this field. Recent findings: ADHD exhibits a high comorbidity rate with anxiety and depressive disorders, due to overlapping and interacting symptoms. Individuals with two or more comorbid conditions often experience increased disease burden, prolonged illness duration, and diminished treatment efficacy. The underlying causes of comorbid anxiety and depression in ADHD patients are highly complex and can be understood from multiple dimensions, including genetics, neurobiology, neurocognition, and neuroimaging. This complexity poses significant challenges for clinical diagnosis and treatment. Currently, the management of ADHD patients with concurrent depression or anxiety may involve pharmaceutical interventions combined with non-pharmacological strategies, including psychotherapy (e.g., cognitive-behavioral therapy, CBT) and digital therapeutics. For patients with comorbid illnesses, these intergrated approaches have demonstrated significant improvements in symptom relief and quality of life enhancement. Summary: ADHD is a highly heterogeneous disorder with a significant comorbidity rate. Recent research has elucidated the pathogenetic mechanisms of ADHD comorbid with depression and anxiety disorders from multiple perspectives. To improve patient functioning, enhance their quality of life, and guide more effective treatments, Further studies are needed to investigate the underlying causes of these comorbid conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.