Evidence map›Paper›PMID 40547078›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

The effect of the EXOPULSE Mollii suit on motor functions in patients with multiple sclerosis - a randomized sham-controlled crossover trial.

Samar S Ayache, Joseph G Mattar, Alain Créange, Mohamed Abdellaoui, Mickael Zedet, Jean-Pascal Lefaucheur, Hana Megherbi, Hayfa Khaled, Georges Naïm Abi Lahoud, Moussa A Chalah

Registry-linked trialAbstract read
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06702137 (The Effects of EXOPULSE Mollii Suit on Motor Functions in Patients With Multiple Sclerosis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06702137 nacompletednot on this map

The Effects of EXOPULSE Mollii Suit on Motor Functions in Patients With Multiple Sclerosis (EXOSEP Study)

TypeinterventionalSponsorInstitut De La Colonne Vertebrale Et Des NeurosciencesRan2022 to 2024Enrolled34ConditionsMultiple SclerosisArmsEXOPULSE MOLLII SUIT (active), EXOPULSE MOLLII SUIT (sham)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samar S AyacheInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico Chirurgical Bizet, Paris, France.ORCID https://orcid.org/0000-0003-0188-1957
Joseph G MattarInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico Chirurgical Bizet, Paris, France.
Alain CréangeExcitabilité Nerveuse et Thérapeutique, Faculté de Santé, Université Paris Est, Créteil, France.ORCID https://orcid.org/0000-0003-3838-1622
Mohamed AbdellaouiService de Neurologie, Hôpital Henri Mondor, Créteil, France.
Mickael ZedetService de Neurologie, Hôpital Henri Mondor, Créteil, France.
Jean-Pascal LefaucheurExcitabilité Nerveuse et Thérapeutique, Faculté de Santé, Université Paris Est, Créteil, France.ORCID https://orcid.org/0000-0002-0294-8239
Hana MegherbiService de Neurologie, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
Hayfa KhaledService de Neurologie, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
Georges Naïm Abi LahoudInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico Chirurgical Bizet, Paris, France.
Moussa A ChalahInstitut de la Colonne Vertébrale et des Neurosciences (ICVNS), Centre Médico Chirurgical Bizet, Paris, France.ORCID https://orcid.org/0000-0002-0880-8608

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with multiple sclerosis (PwMS) could suffer from frequent and disabling motor symptoms, including balance and mobility problems, spasticity, weakness and fatigue, with an impact on patients' quality of life. Current treatments have limited efficacy or significant side effects. The EXOPULSE Mollii Suit, a transcutaneous electrical nerve stimulation system, provides simultaneous stimulation to 40 muscle groups and may offer a therapeutic alternative. Objectives: This study evaluated the effects of this device on balance, other motor symptoms and quality of life in PwMS. Methods: A randomized, crossover, sham-controlled, double-blind study (phase 1) evaluated the effects of a 60-min single session of active versus sham stimulation. An open-label phase 2 evaluated the effects of stimulation over four weeks. Balance (Berg Balance Scale) was the primary outcome, with secondary measures including spasticity, mobility, pain, fatigue and quality of life. Results: Thirty-two patients completed phase 1, and 30 completed phase 2. The intervention was well tolerated. Significant improvements in balance ( Conclusions: The EXOPULSE Molii Suit demonstrated significant benefits for motor symptoms, warranting further large-scale research into long-term effects.This clinical trial was prospectively registered on clinicaltrials.gov as 'EXOPULSE Mollii Suit, Motor Function & Multiple Sclerosis (EXOSEP)' (NCT06702137). https://clinicaltrials.gov/study/NCT06702137?term=NCT06702137&rank=1.

Indexed as

balancemobilityMultiple sclerosisspasticitytranscutaneous electric nerve stimulation

Identifiers

PMID40547078
PMCPMC12179495

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.