Evidence map›Paper›PMID 40547038›Full record

ArticleFrontiers in immunology2025

Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung.

Tao Wang, Jianfeng Hao, Bing Li, Ahjol Hyraht, Jialing Wang, Henglei Xia, Qingbin Wu, Wei Gao, Congxia Chen, Chuanqing Yu and 5 more

Erratum issuedAbstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Tao WangThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Jianfeng Hao *The First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Bing LiSchool of Public Health, Anhui University of Science and Technology, Hefei, Anhui, China.
Ahjol HyrahtState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Jialing WangSchool of Public Health, Anhui University of Science and Technology, Hefei, Anhui, China.
Henglei XiaThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Qingbin WuThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Wei GaoThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Congxia ChenThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Chuanqing YuThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Xiuqun GongThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Ting LiKunshan Integrated Traditional Chinese and Western Medicine Hospital, Kunshan, Jiangsu, China.
Mei ZhangThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Yinghai XieThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.
Xinrong TaoThe First Hospital of Anhui University of Science and Technology (Huainan First People's Hospital), Huainan, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanism that lung epithelial cells regulate immune responses during chronic injury still remains unclear. Here, we combined single-cell RNA sequencing with spatial transcriptomics to track epithelial dynamics in silica (SiO

Indexed as

Epithelial CellsEpithelial-Mesenchymal TransitionLungLung InjurySilicon DioxideTranscriptomeAnimalsCell CommunicationGene Expression ProfilingMiceMice, Inbred C57BLSignal TransductionSingle-Cell AnalysisSilicon Dioxidealveolar epithelial cellsepithelial-immune crosstalksilicosissingle-cell RNA sequencingspatial transcriptomics

Identifiers

PMID40547038
PMCPMC12179088

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.