ArticleClinical Medicine Insights. Oncology2025
Primary Management of Localized Gastrointestinal Stromal Tumors With Imatinib Monotherapy: An Alternative to Resection of Patients Precluded From Surgery.
Article in Clinical Medicine Insights. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In this study, our goal was to elucidate the role for imatinib monotherapy for treatment of patients with localized gastrointestinal stromal tumors (GISTs) who are precluded from standard-of-care surgical resection due to their medical comorbidities or patient preference. Methods: A single-center retrospective study was conducted on a consecutive cohort of adult patients with pathology-confirmed gastrointestinal stromal tumors. The cohort of interest (n = 11) was the subset of patients on imatinib therapy alone with no prior history of curative-intent surgical resection. We analyzed patient demographics, GIST disease characteristics, treatment type, and medical comorbidities at the time of diagnosis. Overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan-Meier univariate analysis. Results: Eleven patients met our inclusion criteria. Median age was 77 years (range 65-82) and 7 patients (64%) were men. Eight cases were gastric primary, 2 cases were duodenal, and 1 was esophageal. Four cases had genomics available, 3 of which harbored KIT mutations. For all cases, the documented mitotic rate was less than 5 per 5 mm Conclusion: Patients tolerated imatinib monotherapy well and demonstrated robust survival data. Our research highlights a new potential application for imatinib in a patient population that has historically been precluded from standard-of-care therapy for their disease.
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