Evidence map›Paper›PMID 40546965›Full record

ArticleiScience2025

Distinct transcriptomic signatures in pulmonary tissue resident and vascular resident-like T cells in nonhuman primates.

Alexandra Melton, E Lake Potter, Toni Penney, Clara Krzykwa, Lori A Rowe, Kelly Goff, Sarah E Scheuermann, Kasi Russell-Lodrigue, Hunter J Melton, Diogo M Magnani and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandra MeltonTulane National Primate Research Center, Covington, LA, USA.
E Lake PotterVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Toni PenneyTulane National Primate Research Center, Covington, LA, USA.
Clara KrzykwaTulane National Primate Research Center, Covington, LA, USA.
Lori A RoweTulane National Primate Research Center, Covington, LA, USA.
Kelly GoffTulane National Primate Research Center, Covington, LA, USA.
Sarah E ScheuermannTulane National Primate Research Center, Covington, LA, USA.
Kasi Russell-LodrigueTulane National Primate Research Center, Covington, LA, USA.
Hunter J MeltonGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Diogo M MagnaniNonhuman Primate Reagent Resource (NHPRR), UMass Chan Medical School, Worcester, MA 01605, USA.
Jay K KollsDepartments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, USA.
Robert V BlairTulane National Primate Research Center, Covington, LA, USA.
Nicholas J ManessTulane National Primate Research Center, Covington, LA, USA.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Training in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3M
High Throughput Multicolor Flow Cytometer Cell AnalyzerS10OD026800 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KAUR, AMITINDER · 2019 to 2019
$594k
Reservoir modulation by Nef and anti-nef CTLR21AI150413 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI MANESS, NICHOLAS JAMES · 2020 to 2021
$468k
NHLBI NIH HHS R35 HL139930NIAID NIH HHS R21 AI150413NIAID NIH HHS U24 AI126683NIH HHS P51 OD011104NIH HHS S10 OD026800
6 · The paper itself

Abstract

The concept of intravascular immunity is reshaping our understanding of immune surveillance, challenging the traditional view that immune responses are confined to either tissue parenchyma or the bloodstream. Our pilot study utilized intravascular staining (ivs) in rhesus macaques (RhM) to spatially distinguish pulmonary vasculature-associated (ivs+) CD8

Indexed as

ImmunityImmunologyTranscriptomics

Identifiers

PMID40546965
PMCPMC12182324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.