Evidence map›Paper›PMID 40546959›Full record

ArticleiScience2025

Osteoprotegerin and its ligands RANKL and TRAIL in falciparum, vivax, and knowlesi malaria.

Arya Sheela Nair, John Woodford, Jessica Loughland, Dean Andrew, Kim Piera, Fiona Amante, Timothy William, Matthew J Grigg, James S McCarthy, Nicholas M Anstey and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Arya Sheela NairQIMR Berghofer, Brisbane, QLD, Australia.
John WoodfordQIMR Berghofer, Brisbane, QLD, Australia.
Jessica LoughlandQIMR Berghofer, Brisbane, QLD, Australia.
Dean AndrewQIMR Berghofer, Brisbane, QLD, Australia.
Kim PieraMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Fiona AmanteQIMR Berghofer, Brisbane, QLD, Australia.
Timothy WilliamSubang Jaya Medical Centre, Selangor, Subang Jaya, Malaysia.
Matthew J GriggMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
James S McCarthyQIMR Berghofer, Brisbane, QLD, Australia.
Nicholas M AnsteyMenzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Michelle J BoyleQIMR Berghofer, Brisbane, QLD, Australia.
Bridget E BarberQIMR Berghofer, Brisbane, QLD, Australia.

Funding

Comparative incidence and clinical spectrum of Plasmodium knowlesi malaria, a longitudinal study in Sabah, MalaysiaR01AI116472 · NIAID · INFECTIOUS DISEASE SOCIETY KOTA KINABALU · PI WILLIAM, TIMOTHY · 2015 to 2019
$682k
NIAID NIH HHS R01 AI116472
6 · The paper itself

Abstract

Osteoprotegerin (OPG), a soluble decoy receptor for receptor activator of NF-ƙB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL), is increasingly recognized as a marker of poor prognosis in cardiovascular disease. Here, we demonstrate that in adults with falciparum and vivax malaria, OPG is increased, and its ligands TRAIL and RANKL decreased, in association with validated markers of disease severity. Using longitudinal samples from malaria volunteer infection studies, we demonstrate that TRAIL is unexpectedly increased in early infection, suggesting binding of OPG to RANKL prior to TRAIL. Finally, in addition to its known vascular origin, we show that

Indexed as

DiseaseImmune responseMolecular biology

Identifiers

PMID40546959
PMCPMC12182329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.