Evidence map›Paper›PMID 40546958›Full record

ArticleiScience2025

The transcription factor ZFP64 promotes activity-dependent synapse elimination during postnatal cerebellar development.

Jianling Zhang, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Kohtarou Konno, Yuto Okuno, Kyoko Matsuyama, Takayuki Noro, Masahiko Watanabe, Naofumi Uesaka and 1 more

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In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jianling ZhangDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Takaki WatanabeDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Taisuke MiyazakiDepartment of Anatomy, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Miwako YamasakiDepartment of Anatomy, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Kohtarou KonnoDepartment of Anatomy, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Yuto OkunoDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Kyoko MatsuyamaDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Takayuki NoroDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Masahiko WatanabeDepartment of Anatomy, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Naofumi UesakaDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan.
Masanobu KanoDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eliminating redundant synapses formed around birth is essential for shaping functionally mature neural circuits during postnatal development. Each Purkinje cell (PC) in the neonatal mouse cerebellum receives synaptic inputs from multiple climbing fibers (CFs). Only one CF is strengthened and extends its innervation over PC dendrites, whereas the other CFs are eventually pruned during postnatal development. These events are believed to require proper gene expression, but the underlying mechanisms are not yet understood. Here, we report that the transcription factor ZFP64 in PCs mediates part of CF synapse elimination events presumably downstream of P/Q-type voltage-dependent Ca

Indexed as

Developmental biologyMolecular physiologyNeuroscience

Identifiers

PMID40546958
PMCPMC12178792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.