ArticleiScience2025
Stress transmission in social groups of mice: unveiling physiological responses, behavioral patterns, and immune dynamics.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The Predictive Accuracy of Methods Commonly Used for Evaluating Animal Distress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- If you give a mouse a poopsicle: a novel fecal microbiota transplant method for exploring the role of the gut microbiome in stress-related outcomes in mice.bioRxiv : the preprint server for biology · 2026Article
- Rhodiola rosea L. roots powder strongly reduces anxiety and corticosterone level induced by chronic stress in a murine model.Journal of pharmaceutical health care and sciences · 2026Article
- If you give a mouse a poopsicle: a novel fecal microbiota transplant method for exploring the role of the gut microbiome in stress-related outcomes in mice.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In modern societies, stress is pervasive, requiring sophisticated physiological mechanisms for stability and survival, primarily through the sympatho-adrenal medullary (SAM) and hypothalamo-pituitary adrenal (HPA) axes. Chronic stress is linked to a range of mental and physical health problems and has been shown to affect immune function. In this study, a paradigm for social stress transmission in groups of mice was established, based on a restraint stress model to study how stress spreads among individuals. Mice exposed to indirect stress exhibited HPA-axis activation, elevated corticosterone (CORT) levels, enlarged adrenal glands, and anxiety-like behaviors in light-dark-box tests. Notably, female mice were more susceptible to stress transmission. While stress transmission enhanced innate immune responses, it did not affect adaptive immunity following vaccination with a poly(lactic-co-glycolic acid) (PLGA)-based vaccine. In contrast, direct stress impaired both immune responses and the effectiveness of immunotherapy in a melanoma model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.