Evidence map›Paper›PMID 40546888›Full record

ArticleMolecular systems design & engineering2019

Role of antibody heavy and light chain interface residues in affinity maturation of binding to HIV envelope glycoprotein.

Alberto Cisneros, Rachel Stecker Nargi, Erica Hammaker Parrish, Christian Marie Haliburton, Jens Meiler, James E Crowe

Abstract read
In one paragraph

Article in Molecular systems design & engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Unique structural solution from a VNature communications · 2021
    Article
  5. H and L Chain Affinity Maturation and/or FabJournal of immunology (Baltimore, Md. : 1950) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alberto CisnerosThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.
Rachel Stecker NargiThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.
Erica Hammaker ParrishThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.
Christian Marie HaliburtonThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.
Jens MeilerDepartment of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, 37232, USA.
James E CroweThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.

Funding

Structure based design of antibodies and vaccinesU19AI117905 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MEILER, JENS · 2015 to 2019
$12.0M
Structural Determinants of Human Antibodies neutralizing the Ebola VirusR21AI121799 · NIAID · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2016 to 2017
$432k
NIAID NIH HHS R21 AI121799NIAID NIH HHS U19 AI117905
6 · The paper itself

Abstract

The F

Identifiers

PMID40546888
PMCPMC12180580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.