ArticleJournal of conservative dentistry and endodontics2025
Cytotoxicity of chitosan-loaded triple antibiotic paste versus conventional triple antibiotic paste on dental pulp stem cells: An
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative outcomes and success rates of regenerative endodontics versus traditional root canal therapy: A systematic review and meta-analysis.The Journal of international medical research · 2025Pooled it
- Direct effect of nitrofurantoin on dental pulp stem cell viability and odontoblastic differentiation potential.Journal of conservative dentistry and endodontics · 2026Article
- Cytocompatibility of calcium hydroxide medicament combined with cationic peptide - AnJournal of conservative dentistry and endodontics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Triple antibiotic paste (TAP) is a commonly used intracanal medicament in regenerative endodontics. However, its cytotoxic effects on dental pulp stem cells (DPSCs) remain a concern. Incorporating chitosan into TAP may enhance its biocompatibility while retaining antimicrobial properties. Aim: The aim of this study was to evaluate and compare the cytotoxicity of chitosan-loaded TAP (Ch-TAP) with conventional TAP on DPSCs at varying concentrations and time intervals. Materials and Methods: DPSCs were exposed to Ch-TAP and TAP at concentrations of 0.1-100. Cell viability was assessed at 1-4 weeks using an MTT assay. The results were statistically analyzed using one-way ANOVA and Results: Ch-TAP demonstrated superior cell viability at all concentrations compared to TAP. The highest cell viability was observed with Ch-TAP at 0.1 mg/mL, maintaining 96% viability at 1 week and 85% at 4 weeks. Higher concentrations of both pastes exhibited a dose dependent decrease in cell viability, with Ch-TAP consistently showing less cytotoxicity. TAP at 100 mg/mL exhibited the highest cytotoxicity, reducing viability to 20% by the 4 Conclusion: Ch-TAP showed significantly lower cytotoxicity and better biocompatibility with DPSCs compared to conventional TAP, particularly at lower concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.