ArticleJournal of conservative dentistry and endodontics2025
Change in serum biomarker levels in patients of apical periodontitis after root canal treatment using two different root canal sealers: A randomized controlled trial.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Aim: The aim of the study was to comparatively evaluate the difference in serum pro-inflammatory (soluble cluster of differentiation-14 [sCD14]) and anti-inflammatory (interleukin-10 [IL-10]) biomarkers levels when 2 different root canal sealers are used during root canal treatment (RCT) in systemically healthy patients with apical periodontitis. Methods: The study was a parallel double-blind randomized clinical trial; 54 carious mature permanent teeth with apical periodontitis were randomized using a block randomization technique to either Group 1 (Tubli-seal) ( Results: In Group 1, pro-inflammatory biomarker (sCD-14) demonstrated statistically significant results ( Conclusion: RCT reduces serum pro-inflammatory biomarker levels and no significant changes in levels of anti-inflammatory biomarkers in patients of apical periodontitis.
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