ArticleGland surgery2025
Intrathyroidal parathyroid carcinoma masquerading as a cystic thyroid nodule: a case report.
Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Parathyroid carcinomas (PCs) are uncommon malignancies, accounting for an estimated 0.005% of all cancers. Intrathyroidal PCs are exceedingly rare, with fewer than 20 reported cases. Severe hypercalcemia and high parathyroid hormone (PTH) levels at presentation are risk factors for PC. The majority of cases are diagnosed postoperatively. Preoperative localization of PC can be challenging, especially in cystic lesions, where the lack of oxyphil cell predominance may reduce the sensitivity of technetium-99m ( Case Description: We report a female patient diagnosed with primary hyperparathyroidism, presenting with a PTH level of 192 pmol/L (1.8-8 pmol/L) and severe hypercalcemia. Preoperative Conclusions: This case highlights an unusual presentation of PC masquerading as a cystic thyroid nodule. Clinicians should consider PC in the differential diagnosis of cystic neck lesions. Aspiration of cystic fluid for PTH assay may be a valuable adjunct in diagnosis, though further evidence is needed.
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