Evidence map›Paper›PMID 40546821›Full record

ArticleBioinformatics advances2025

VaxGO: an interactive web tool for systems vaccinology data analysis.

Wasim Aluísio Prates-Syed, Aline Aparecida Lima, Nelson Cortes, Evelyn Carvalho, Jaqueline Dinis Queiroz Silva, Bárbara Hamaguchi, Ricardo Durães-Carvalho, Otávio Cabral-Marques, Thomas Hagan, José E Krieger and 1 more

Abstract read
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wasim Aluísio Prates-SyedInstitute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.
Aline Aparecida LimaInstitute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.
Nelson CortesInstitute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.
Evelyn CarvalhoInstitute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.
Jaqueline Dinis Queiroz SilvaInstitute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.
Bárbara HamaguchiInstitute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.
Ricardo Durães-CarvalhoDepartment of Microbiology, Immunology and Parasitology, São Paulo School of Medicine, Federal University of São Paulo, São Paulo, 04023-062, Brazil.
Otávio Cabral-MarquesBiomedical Sciences Institute, University of São Paulo, São Paulo, 05508-000, Brazil.
Thomas HaganCincinnati Children's Hospital, Cincinnati, OH, 45229, United States.
José E KriegerHeart Institute, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, 05403-900, Brazil.
Gustavo Cabral-MirandaInstitute of Tropical Medicine, Faculty of Medicine of the University of São Paulo, São Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0001-8351-4880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: RNA sequencing is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNA sequencing data often requires programming skills, which can limit accessibility for researchers lacking such expertise. Results: We present VaxGO, an intuitive web-based tool designed to facilitate the analysis of differentially expressed genes in the context of immune processes and cells during vaccination. This tool integrates data from Gene Ontology, CellMarker 2.0, the MSigDB Vax collection, and other key studies, including transcriptional atlases of vaccines against COVID-19 and other diseases. VaxGO is an interactive, web-based tool, offering a user-friendly platform for exploring immune responses and vaccine efficacy without programming expertise. Availability and implementation: The VaxGO tool is available at https://github.com/wapsyed/VaxGO.

Identifiers

PMID40546821
PMCPMC12179387

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.