Evidence map›Paper›PMID 40546819›Full record

ArticleBioinformatics advances2025

Alexandre Oliveira, Jorge Ferreira, Vítor Vieira, Bruno Sá, Miguel Rocha

Abstract read
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandre OliveiraCentre of Biological Engineering, University of Minho, Braga 4710-057, Portugal.ORCID https://orcid.org/0000-0002-2255-8983
Jorge FerreiraCentre of Biological Engineering, University of Minho, Braga 4710-057, Portugal.
Vítor VieiraCentre of Biological Engineering, University of Minho, Braga 4710-057, Portugal.
Bruno SáCentre of Biological Engineering, University of Minho, Braga 4710-057, Portugal.
Miguel RochaCentre of Biological Engineering, University of Minho, Braga 4710-057, Portugal.ORCID https://orcid.org/0000-0001-8439-8172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Summary: The increasing availability of high-throughput technologies in systems biology has advanced predictive tools like genome-scale metabolic models. Despite this progress, integrating omics data to create accurate, context-specific metabolic models for different tissues or cells remains challenging. A significant issue is that many existing tools rely on proprietary software, which limits accessibility. We introduce TROPPO, an open-source Python library designed to overcome these challenges. TROPPO supports a wide range of context-specific reconstruction algorithms, provides validation methods for assessing generated models, and includes gap-filling algorithms to ensure model consistency, integrating well with other constraint-based tools. Availability and implementation: TROPPO is implemented in Python and is freely available at https://github.com/BioSystemsUM/TROPPO and https://pypi.org/project/TROPPO/.

Identifiers

PMID40546819
PMCPMC12179386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.