Evidence map›Paper›PMID 40546804›Full record

ReviewInternational journal of nanomedicine2025

Research Progress of Multifunctional Hydrogels in Promoting Wound Healing of Diabetes.

Jiansong He, Jiemei Chen, Taotao Liu, Fuli Qin, Weipeng Wei

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Microorganisms · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiansong HeDepartment of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.ORCID 0009-0002-5574-6478
Jiemei ChenDepartment of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Taotao LiuDepartment of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.ORCID 0000-0001-9467-920X
Fuli QinDepartment of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Weipeng WeiDepartment of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wound healing represents a crucial and complex subject in clinical medicine, because of its physiological mechanism and pathological state, the conventional treatment methods are often limited. In recent years, multifunctional hydrogels have emerged as a focal point in the research field regarding the healing of diabetic wounds. This is attributed to their outstanding biocompatibility, the capacity for controlling drug release, and the traits of facilitating cell migration and proliferation. This paper reviews the fundamental materials, modification strategies for functionality, the principles underlying drug release, and the latest application advancements of multifunctional hydrogels in the context of facilitating the healing process of diabetic wounds. By introducing bioactive molecules and utilizing 3D bioprinting technology, researchers continue to optimize the properties of hydrogels to adapt to various wound conditions, which demonstrates great promise in the use of wound dressings. Taking the microenvironment of diabetic wounds into consideration, strategies for antibacterial, anti-inflammatory, immunomodulatory, antioxidant, and pro-angiogenic effects are integrated with multifunctional hydrogels. This paper systematically analyzes the existing challenges and explores the future research directions, and emphasizes the potential of multifunctional hydrogels in improving wound healing of diabetes and their clinical application prospects.

Indexed as

Diabetes MellitusHydrogelsWound HealingAnimalsBiocompatible MaterialsBioprintingDrug LiberationHumansBiocompatible MaterialsHydrogelsdiabetic woundhydrogelsmulti-functionalwound dressing

Identifiers

PMID40546804
PMCPMC12180465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.