Evidence map›Paper›PMID 40546733›Full record

ArticleFrontiers in bioinformatics2025

DeepPredict: a state-of-the-art web server for protein secondary structure and relative solvent accessibility prediction.

Wafa Alanazi, Di Meng, Gianluca Pollastri

Abstract read
In one paragraph

Article in Frontiers in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Residue burial encodes a protein's fold.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wafa AlanaziSchool of Computer Science, University College Dublin, Dublin, Ireland.
Di MengSchool of Computer Science, University College Dublin, Dublin, Ireland.
Gianluca PollastriSchool of Computer Science, University College Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DeepPredict is a freely accessible web server that integrates Porter6 and PaleAle6, two state-of-the-art deep learning models designed for protein secondary structure prediction (PSSP) and relative solvent accessibility (RSA) prediction, respectively. Built on an advanced deep learning framework, DeepPredict leverages pre-trained protein language models (PLMs), specifically ESM-2, to eliminate the need for multiple sequence alignments (MSAs), enabling rapid and accurate predictions. Compared to existing methods, DeepPredict outperforms in both PSSP and RSA prediction tasks, delivering state-of-the-art performance. The server offers a user-friendly interface, catering to both computational biologists and experimental researchers. DeepPredict is available at [ https://pcrgwd.ucd.ie/wafa/] with comprehensive online documentation and downloadable example datasets.

Indexed as

bioinformaticscomputational biologydeep learningprotein language modelsprotein structure predictionweb server

Identifiers

PMID40546733
PMCPMC12179536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.