Evidence map›Paper›PMID 40546732›Full record

ArticleFrontiers in bioinformatics2025

Interactive visualization of large molecular systems with VTX: example with a minimal whole-cell model.

Maxime Maria, Valentin Guillaume, Simon Guionnière, Nicolas Dacquay, Cyprien Plateau-Holleville, Vincent Larroque, Jean Lardé, Yassine Naimi, Jean-Philip Piquemal, Guillaume Levieux and 3 more

Abstract read
In one paragraph

Article in Frontiers in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maxime MariaXLIM, UMR CNRS 7252, Université de Limoges, Limoges, France.
Valentin GuillaumeLaboratoire GBCM, EA 7528, Conservatoire National des Artset Métiers, Paris, France.
Simon GuionnièreLaboratoire GBCM, EA 7528, Conservatoire National des Artset Métiers, Paris, France.
Nicolas DacquayLaboratoire GBCM, EA 7528, Conservatoire National des Artset Métiers, Paris, France.
Cyprien Plateau-HollevilleXLIM, UMR CNRS 7252, Université de Limoges, Limoges, France.
Vincent LarroqueXLIM, UMR CNRS 7252, Université de Limoges, Limoges, France.
Jean LardéLaboratoire GBCM, EA 7528, Conservatoire National des Artset Métiers, Paris, France.
Yassine NaimiQubit Pharmaceuticals SAS, Paris, France.
Jean-Philip PiquemalLCT, UMR 7616 CNRS, Sorbonne Université, Paris, France.
Guillaume LevieuxLaboratoire CEDRIC, EA 4626, Conservatoire National des Arts et Métiers, Paris, France.
Nathalie LagardeLaboratoire GBCM, EA 7528, Conservatoire National des Artset Métiers, Paris, France.
Stéphane MérillouXLIM, UMR CNRS 7252, Université de Limoges, Limoges, France.
Matthieu MontesLaboratoire GBCM, EA 7528, Conservatoire National des Artset Métiers, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

VTX is an open-source molecular visualization software designed to overcome the scaling limitations of existing real-time molecular visualization software when handling massive molecular datasets. VTX employs a meshless molecular graphics engine utilizing impostor-based techniques and adaptive level-of-detail (LOD) rendering. This approach significantly reduces memory usage and enables real-time visualization and manipulation of large molecular systems. Performance benchmarks against VMD, PyMOL, and ChimeraX using a 114-million-bead Martini minimal whole-cell model demonstrate VTX's efficiency, maintaining consistent frame rates even under interactive manipulation on standard computer hardware. VTX incorporates features such as Screen-Space Ambient Occlusion (SSAO) for enhanced depth perception and free-fly navigation for intuitive exploration of large molecular systems. VTX is open-source and free for non commercial use. Binaries for Windows and Ubuntu Linux are available at http://vtx.drugdesign.fr. VTX source code is available at https://github.com/VTX-Molecular-Visualization.

Indexed as

high-performance computingmolecular dynamicsmolecular graphicsmolecular modelingmolecular visualizationprotein structurestructural biologyusability

Identifiers

PMID40546732
PMCPMC12179134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.