ArticleCase reports in oncology
Consecutive Uncontrolled Gastrointestinal Immune-Related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma: A Case Report.
Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Introduction: Immune-checkpoint inhibitors, such as pembrolizumab, have been used for non-small cell lung cancer treatment but are often associated with immune-related adverse events (irAEs). Case Presentation: A 71-year-old female was diagnosed with lung adenocarcinoma (cT3N0M1c; BRN, cStage IVB [UICC-8th edition]) and was treated with pembrolizumab monotherapy, achieving a partial response. After five cycles, she developed anorexia and abdominal pain, and upper gastrointestinal endoscopy revealed hemorrhagic gastritis because of irAEs. Systemic steroids improved the gastritis, and pembrolizumab was re-administered. However, after re-treatment, she developed interstitial lung disease, enteritis, and recurrent gastritis, all of which were irAEs. Despite high-dose steroids and infliximab addition, the irAEs remained uncontrolled, and the patient eventually died. Conclusion: Caution is essential when re-administering immune-checkpoint inhibitors to patients with prior irAEs, although upper gastrointestinal irAEs are usually manageable.
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