Evidence map›Paper›PMID 40546695›Full record

ReviewRSC advances2025

Recent advances in nano vehicles encapsulating cinnamic acid and its derivatives as promising anticancer agents.

Nadine Wafik Nabih, Mohamed S Nafie, Asaad Babker, Hatem A F M Hassan, Sherif Ashraf Fahmy

Abstract readReview
In one paragraph

Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Molecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nadine Wafik NabihOrganic and Medicinal Chemistry Department, Faculty of Pharmacy, University of Sadat City Sadat City Menoufia 32897 Egypt.ORCID https://orcid.org/0000-0002-2893-8979
Mohamed S NafieDepartment of Chemistry, College of Sciences, University of Sharjah Sharjah P. O. 27272 United Arab Emirates Mohamed.ElSayed@sharjah.ac.ae mohamed_nafie@science.suez.edu.eg.ORCID https://orcid.org/0000-0003-4454-6390
Asaad BabkerDepartment of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University Ajman United Arab Emirates.ORCID https://orcid.org/0000-0002-5022-5676
Hatem A F M HassanMedway School of Pharmacy, University of Kent Chatham Maritime Kent ME4 4TB UK H.A.Hassan@kent.ac.uk.ORCID https://orcid.org/0009-0009-7493-8564
Sherif Ashraf FahmyDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg Robert-Koch-Str. 4 35037 Marburg Germany sheriffahmy@aucegypt.edu sherif.fahmy@pharmazie.uni-marburg.de.ORCID https://orcid.org/0000-0003-3056-8281

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although progress in cancer diagnosis and treatment has been substantial over recent decades, several challenges remain unresolved. Among these challenges are drug resistance, the recurrence of metastatic disease, off-target toxic effects, and nonselective drug targeting. In response, increasing attention has turned to naturally derived anticancer agents that may offer both efficacy and improved safety profiles. Among these, cinnamic acid, a phenylacrylic compound abundant in Lauraceae plants such as cinnamon, has shown remarkable antitumor activity against several cancer types. However, like many phytochemicals, its clinical utility is hampered by poor water solubility, low bioavailability, and unstable pharmacokinetics. In recent years, integrating nanotechnology into drug delivery strategies has opened new avenues for overcoming these limitations. This review explores the most recent developments in the nanoformulation of cinnamic acid and its derivatives, focusing on how nanocarriers may enhance their therapeutic potential in both

Identifiers

PMID40546695
PMCPMC12180521

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.