Evidence map›Paper›PMID 40546675›Full record

ReviewWorld journal of experimental medicine2025

Dynamics of inflammatory signals within the tumor microenvironment.

Hala Issa, Lokjan Singh, Kok-Song Lai, Tina Parusheva-Borsitzky, Shamshul Ansari

Abstract readReview
In one paragraph

Review in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Pathogenicity ofWorld journal of clinical oncology · 2025
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hala IssaDivision of Health Sciences, Higher Colleges of Technology, Abu Dhabi 25026, United Arab Emirates.
Lokjan SinghDepartment of Microbiology, Karnali Academy of Health Sciences, Jumla 21200, Karnali, Nepal.
Kok-Song LaiDivision of Health Sciences, Higher Colleges of Technology, Abu Dhabi 25026, United Arab Emirates.
Tina Parusheva-BorsitzkyDivision of Health Sciences, Higher Colleges of Technology, Abu Dhabi 25026, United Arab Emirates.
Shamshul AnsariDivision of Health Sciences, Higher Colleges of Technology, Abu Dhabi 25026, United Arab Emirates. shamshulansari483@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor stroma, or tumor microenvironment (TME), has been in the spotlight during recent years for its role in tumor development, growth, and metastasis. It consists of a myriad of elements, including tumor-associated macrophages, cancer-associated fibroblasts, a deregulated extracellular matrix, endothelial cells, and vascular vessels. The release of proinflammatory molecules, due to the inflamed microenvironment, such as cytokines and chemokines is found to play a pivotal role in progression of cancer and response to therapy. This review discusses the major key players and important chemical inflammatory signals released in the TME

Indexed as

CytokinesInflammatory signalsInterleukinsTransforming growth factorTumor microenvironment

Identifiers

PMID40546675
PMCPMC12019612

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.