Evidence map›Paper›PMID 40546671›Full record

ArticleWorld journal of experimental medicine2025

Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma.

Felipe Martins Silveira, Lauren Frenzel Schuch, Vanesa Pereira-Prado, Nelly Molina-Frechero, Sandra Lopez-Verdin, Marcelo Gómez Palacio-Gastélum, Miguel Arocena, Sven Niklander, Estefania Sicco, Ronell Bologna-Molina

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Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Felipe Martins SilveiraMolecular Pathology Area, Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay.
Lauren Frenzel SchuchMolecular Pathology Area, Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay.
Vanesa Pereira-PradoMolecular Pathology Area, Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay.
Nelly Molina-FrecheroDivision of Biological and Health Sciences, Autonomous Metropolitan University, Coyoacan 04960, Mexico.
Sandra Lopez-VerdinHealth Science Center, Research Institute of Dentistry, Universidad de Guadalajara, Guadalajara 44100, Jalisco, Mexico.
Marcelo Gómez Palacio-GastélumDepartment of Research, Universidad Juarez del Estado de Durango, Durango 34000, Mexico.
Miguel ArocenaDepartamento de Biología Odontológica, Facultad de Odontología, Universidad de la República, Montevideo 11600, Uruguay.
Sven NiklanderUnit of Oral Pathology and Medicine, Faculty of Dentistry, Universidad Andres Bello, Viña del Mar 2520000, Chile.
Estefania SiccoMolecular Pathology Area, Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay.
Ronell Bologna-MolinaMolecular Pathology Area, Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoxia in oral cancer promotes tumoral invasion by inducing epithelial-mesenchymal transition, leading to aggressive tumor progression.

aimTo characterize the expression of hypoxia-inducible factor 1-alpha (HIF-1α) at the invasive tumor front (ITF) in comparison to tumor islands (TI) in oral squamous cell carcinoma (OSCC) and to explore its relationship with E-cadherin and Vimentin expression.

methodsThirty-eight cases of OSCC and five cases of normal oral mucosa (NOM) were included in this study. The ITF was identified based on the region and immune expression of AE1/AE3. Immunohistochemistry was performed to assess the expression of HIF-1α, Vimentin, and E-cadherin. The immunostaining was analyzed using an immunoreactive score, and the results were illustrated using immunofluorescence.

resultsHIF-1α expression was significantly higher in the TI region compared to the ITF region (

conclusionBased on the results of this study, HIF-1α appears to play a distinct role in OSCC tumor progression, underscoring the importance of exploring hypoxia-driven changes in cellular phenotype at the ITF of OSCC. Further research is needed to better understand their impact on OSCC prognosis.

Indexed as

E-cadherinHypoxia-inducible factor-1αImmunohistochemistryOral squamous cell carcinomaVimentin

Identifiers

PMID40546671
PMCPMC12019610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.